Price range: $268.00 through $328.00
Background:
function:May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donnors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner., similarity:Contains 1 homeobox DNA-binding domain., similarity:Contains 1 TLC (TRAM/LAG1/CLN8) domain.,
| Size | 50μL/100μL |
| Target | LASS4 |
| Reactivity | Human, Mouse |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 46kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human LASS4. AA range:41-90 |
| Specificity | LASS4 Polyclonal Antibody detects endogenous levels of LASS4 protein. |
| Gene Name | CERS4 |
| Protein Name | Ceramide synthase 4 |
| Other Name | CERS4; / LASS4; / Ceramide synthase 4; / CerS4; / LAG1 longevity assurance homolog 4 |
| Species | Human |
| Gene ID | 79603 |
| Uniprot | Q9HA82, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9D6J1 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Endoplasmic reticulum membrane; Multi-pass membrane protein . |
| Tissue Expression | Cerebellum,Embryo,Lung, |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> Sphingolipid signaling pathway |
| Research Areas | >>Sphingolipid metabolism; / >>Metabolic pathways; / >>Sphingolipid signaling pathway |
| Function | Function:May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donnors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 1 TLC (TRAM/LAG1/CLN8) domain., |
