LCAP Polyclonal Antibody
Ucallm_WP3189-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | LCAP |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 112kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein AA range: 705-755 |
| Specificity | LCAP Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | LNPEP OTASE |
| Protein Name | Leucyl-cystinyl aminopeptidase (Cystinyl aminopeptidase) (Insulin-regulated membrane aminopeptidase) (Insulin-responsive aminopeptidase) (IRAP) (Oxytocinase) (OTase) (Placental leucine aminopeptidase) (P-LAP) [Cleaved into: Leucyl-cystinyl aminopeptidase, pregnancy serum form] |
| Other Name | |
| Species | Human |
| Gene ID | 4012 |
| Uniprot | Q9UIQ6, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8C129, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P97629 |
| Cellular Localization | Cell membrane; Single-pass type II membrane protein . In brain only the membrane-bound form is found. The protein resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin. Localization may be determined by dileucine internalization motifs, and/or by interaction with tankyrases.; [Leucyl-cystinyl aminopeptidase, pregnancy serum form]: Secreted. During pregnancy serum levels are low in the first trimester, rise progressively during the second and third trimester and decrease rapidly after parturition. |
| Tissue Expression | Highly expressed in placenta, heart, kidney and small intestine. Detected at lower levels in neuronal cells in the brain, in skeletal muscle, spleen, liver, testes and colon. |
| Signaling_pathway | Organismal Systems >> Endocrine system >> Renin-angiotensin system |
| Research Areas | >>Renin-angiotensin system |
| Function | Alternative products:Experimental confirmation may be lacking for some isoforms,Catalytic activity:Release of an N-terminal amino acid, Cys-|-Xaa-, in which the half-cystine residue is involved in a disulfide loop, notably in oxytocin or vasopressin. Hydrolysis rates on a range of aminoacyl arylamides exceed that for the cystinyl derivative, however.,cofactor:Binds 1 zinc ion per subunit.,Function:Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain.,PTM:N-glycosylated.,PTM:The pregnancy serum form is derived from the membrane-bound form by proteolytic processing.,similarity:Belongs to the peptidase M1 family.,subcellular location:During pregnancy serum levels are low in the first trimester, rise progressively during the second and third trimester and decrease rapidly after parturition.,subcellular location:In brain only the membrane-bound form is found. The protein resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin. Localization may be determined by dileucine internalization motifs, and/or by interaction with tankyrases.,subunit:Homodimer. Binds tankyrases 1 and 2.,tissue specificity:Highly expressed in placenta, heart, kidney and small intestine. Detected at lower levels in neuronal cells in the brain, in skeletal muscle, spleen, liver, testes and colon., |
Please login to post questions
Related products
