Name: U-Blot® LDLR Rabbit mAb
SKU: WR4901
Price: 268 USD
Availability: InStock

U-Blot® LDLR Rabbit mAb

Ucallm_WR4901-50

Price range: $268.00 through $328.00

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50μl

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SKU: WR4901-50

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Product details

Background:The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010],

Specifications

Size	50μL/100μL
Target	LDLR
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)	95kD
MW(Observed)	130kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:1000-1:4000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM1074R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	LDLR
Protein Name	Low-density lipoprotein receptor (LDL receptor)
Other Name
Species	Human
Gene ID	3949
Uniprot	P01130,
Species.1	Mouse
Gene ID.1
Uniprot.1	P35951,
Species.2	Rat
Gene ID.2
Uniprot.2	P35952
Cellular Localization	Cell membrane; Single-pass type I membrane protein . Membrane, clathrin-coated pit . Golgi apparatus . Early endosome . Late endosome . Lysosome . Rapidly endocytosed upon ligand binding. .
Tissue Expression	Brain,Liver,Lymph,Plasma,
Signaling_pathway	Organismal Systems >> Endocrine system >> Aldosterone synthesis and secretion
Research Areas	>>Endocytosis; / >>Ovarian steroidogenesis; / >>Aldosterone synthesis and secretion; / >>Cortisol synthesis and secretion; / >>Cushing syndrome; / >>Bile secretion; / >>Cholesterol metabolism; / >>Toxoplasmosis; / >>Hepatitis C; / >>Lipid and atherosclerosis
Function	Disease:Defects in LDLR are the cause of familial hypercholesterolemia (FH) [MIM:143890]; a common autosomal semi-dominant disease that affects about 1 in 500 individuals. The receptor defect impairs the catabolism of LDL, and the resultant elevation in plasma LDL-cholesterol promotes deposition of cholesterol in the skin (xanthelasma), tendons (xanthomas), and coronary arteries (atherosclerosis).,Function:Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells.,online information:LDLR mutation database,online information:The Singapore human mutation and polymorphism database,PTM:N- and O-glycosylated.,similarity:Belongs to the LDLR family.,similarity:Contains 3 EGF-like domains.,similarity:Contains 6 LDL-receptor class B repeats.,similarity:Contains 7 LDL-receptor class A domains.,subunit:Interacts with LDLRAP1. Interacts with SNX17. Interacts with HCV E1/E2 heterodimer. Interacts with HIV-1 Tat.,