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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/Lefty Polyclonal Antibody
SKU: WP15641 Categories: ,

Lefty Polyclonal Antibody

Ucallm_WP15641-50

Price range: $268.00 through $328.00

SKU: WP15641-100
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Product details

Background:

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. This gene is closely linked to both a related family member and a related pseudogene. [provided by RefSeq, Aug 2016],

Specifications

Size50μL/100μL
TargetLefty
ReactivityHuman, Mouse
ApplicationsWB, IHC
MW(Calculated)
MW(Observed)40kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; IHC 1:50-300 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from the C-terminal region of human LEFTY1/LEFTY2. AA range:301-350
SpecificityLefty Polyclonal Antibody detects endogenous levels of Lefty protein.
Gene NameLEFTY1/LEFTY2
Protein NameLeft-right determination factor 1/Left-right determination factor 2
Other NameLEFTY1; / LEFTB; / LEFTYB; / Left-right determination factor 1; / Left-right determination factor B; / Protein lefty-1; / Protein lefty-B; / LEFTY2; / EBAF; / LEFTA; / LEFTYA; / TGFB4; / PSEC0024; / Left-right determination factor 2; / Endometrial bleeding-associated factor; / Left-right determination factor A; / Protein lefty-2; / Protein lefty-A; / Transforming growth factor beta-4; / TGF-beta-4
SpeciesHuman
Gene ID10637;7044
UniprotO75610;O00292,
Species.1Mouse
Gene ID.113590;320202
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationSecreted.
Tissue ExpressionColon,Pancreas,Spleen,Teratocarcinoma,
Signaling_pathwayCellular Processes >> Cellular community - eukaryotes >> Signaling pathways regulating pluripotency of stem cells;Environmental Information Processing >> Signal transduction >> TGF-beta signaling pathway
Research Areas>>TGF-beta signaling pathway; / >>Signaling pathways regulating pluripotency of stem cells
FunctionFunction:Required for left-right axis determination as a regulator of LEFTY2 and NODAL.,PTM:The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.,similarity:Belongs to the TGF-beta family.,
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