LHR Polyclonal Antibody
Ucallm_WP12996-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | LHR |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IF, ELISA, IHC |
| MW(Calculated) | |
| MW(Observed) | 80kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-300; IF 1:200-1:1000; ELISA 1:2000-20000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human LSHR. AA range:621-670 |
| Specificity | LHR Polyclonal Antibody detects endogenous levels of LHR protein. |
| Gene Name | LHCGR LCGR LGR2 LHRHR |
| Protein Name | Lutropin-choriogonadotropic hormone receptor |
| Other Name | LHCGR; / LCGR; / LGR2; / LHRHR; / Lutropin-choriogonadotropic hormone receptor; / LH/CG-R; / Luteinizing hormone receptor; / LHR; / LSH-R |
| Species | Human |
| Gene ID | 3973 |
| Uniprot | P22888, |
| Species.1 | Mouse |
| Gene ID.1 | 16867 |
| Uniprot.1 | P30730, |
| Species.2 | Rat |
| Gene ID.2 | 25477 |
| Uniprot.2 | P16235 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . |
| Tissue Expression | Gonadal and thyroid cells. |
| Signaling_pathway | Organismal Systems >> Endocrine system >> Prolactin signaling pathway;Environmental Information Processing >> Signal transduction >> Calcium signaling pathway;Environmental Information Processing >> Signal transduction >> cAMP signaling pathway |
| Research Areas | >>Calcium signaling pathway; / >>cAMP signaling pathway; / >>Neuroactive ligand-receptor interaction; / >>Ovarian steroidogenesis; / >>Prolactin signaling pathway |
| Function | Alternative products:Additional isoforms seem to exist,Disease:Defects in LHCGR are a cause of familial male precocious puberty (FMPP) [MIM:176410]; also known as testotoxicosis. In FMPP the receptor is constitutively activated.,Disease:Defects in LHCGR are a cause of Leydig cell hypoplasia (LCH) [MIM:152790]. LCH is an autosomal recessive disease characterized by male pseudohermaphroditism. In LCH the testes are small with marked immaturity of the Leydig cells which correlates with undetectable plasma testosterone levels and elevated gonadotropins.,Function:Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.,online information:Glycoprotein-hormone Receptors Information System,similarity:Belongs to the G-protein coupled receptor 1 family.,similarity:Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.,similarity:Contains 7 LRR (leucine-rich) repeats.,tissue specificity:Gonadal and thyroid cells., |
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