Price range: $268.00 through $328.00
Background:
This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor important for the development of the renal and urogenital systems. This gene is a candidate for Mayer-Rokitansky-Kuster-Hauser syndrome, a disorder characterized by anomalies in the female genital tract. [provided by RefSeq, Dec 2010],
| Size | 50μL/100μL |
| Target | LHX1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 44kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from the Internal region of human LHX1. |
| Specificity | LHX1 Polyclonal Antibody detects endogenous levels of LHX1 protein. |
| Gene Name | LHX1 |
| Protein Name | LIM/homeobox protein Lhx1 |
| Other Name | LHX1; / LIM-1; / LIM1; / LIM/homeobox protein Lhx1; / LIM homeobox protein 1; / Homeobox protein Lim-1; / hLim-1 |
| Species | Human |
| Gene ID | 3975 |
| Uniprot | P48742, |
| Species.1 | Mouse |
| Gene ID.1 | 16869 |
| Uniprot.1 | P63006, |
| Species.2 | Rat |
| Gene ID.2 | 257634 |
| Uniprot.2 | P63007 |
| Cellular Localization | Nucleus . |
| Tissue Expression | Expressed in the brain, thymus, and tonsils. Expressed in samples from patients with chronic myeloid leukemia (CML) and in 58% of acute myeloid leukemia (AML) cell lines. |
| Signaling_pathway | |
| Research Areas | |
| Function | Domain:The LIM domains exert a negative regulatory function and disruption of the LIM domains produces an activated form. In addition, two activation domains and a negative regulatory domain exist C-terminally to the homeobox.,Function:Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 2 LIM zinc-binding domains.,subunit:Interacts with LDB1 via the tandem LIM domains.,tissue specificity:Expressed in the brain, thymus, and tonsils. Expressed in samples from patients with chronic myeloid leukemia (CML) and in 58% of acute myeloid leukemia (AML) cell lines., |
