Name: LIF Polyclonal Antibody
SKU: WP15200
Price: 268 USD
Availability: InStock

LIF Polyclonal Antibody

Ucallm_WP15200-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP15200-100

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Product details

Background:

leukemia inhibitory factor(LIF) Homo sapiens The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012],

Specifications

Size	50μL/100μL
Target	LIF
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	25kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC: 1:100-300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from the C-terminal region of human LIF. AA range:141-190
Specificity	LIF Polyclonal Antibody detects endogenous levels of LIF protein.
Gene Name	LIF
Protein Name	Leukemia inhibitory factor
Other Name	LIF; / HILDA; / Leukemia inhibitory factor; / LIF; / Differentiation-stimulating factor; / D factor; / Melanoma-derived LPL inhibitor; / MLPLI; / Emfilermin
Species	Human
Gene ID	3976
Uniprot	P15018,
Species.1	Mouse
Gene ID.1
Uniprot.1	P09056
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Secreted.
Tissue Expression	Colon,
Signaling_pathway	Cellular Processes >> Cellular community - eukaryotes >> Signaling pathways regulating pluripotency of stem cells;Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway;Environmental Information Processing >> Signal transduction >> TNF signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction
Research Areas	>>Cytokine-cytokine receptor interaction; / >>Signaling pathways regulating pluripotency of stem cells; / >>JAK-STAT signaling pathway; / >>TNF signaling pathway
Function	Function:LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.,online information:Leukemia inhibitory factor entry,pharmaceutical:In phase II clinical trial. The drug is being developed by Amrad to assist embryo implantation in women who have failed to become pregnant despite assisted reproductive technologies (ART).,similarity:Belongs to the LIF/OSM family.,