Product details
Background:
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LIN7C rabbit pAb
Ucallm_WP7126-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | LIN7C |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 22kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human LIN7C |
| Specificity | This antibody detects endogenous levels of LIN7C at Human, Mouse,Rat |
| Gene Name | LIN7C MALS3 VELI3 |
| Protein Name | Protein lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3) |
| Other Name | |
| Species | Human |
| Gene ID | 55327 |
| Uniprot | Q9NUP9, |
| Species.1 | Mouse |
| Gene ID.1 | 22343 |
| Uniprot.1 | O88952, |
| Species.2 | Rat |
| Gene ID.2 | 60442 |
| Uniprot.2 | Q792I0 |
| Cellular Localization | Cell membrane; Peripheral membrane protein . Basolateral cell membrane; Peripheral membrane protein . Cell junction . Cell junction, synapse, postsynaptic density membrane; Peripheral membrane protein . Cell junction, tight junction . Mainly basolateral in renal epithelial cells. . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. |
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