SKU: WP0556 Categories: ,

LMTK1 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP0556-100
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Product details

Background:

The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011],

Specifications

Size50μL/100μL
TargetLMTK1
ReactivityHuman, Mouse
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)151kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human protein . at AA range: 1110-1190
SpecificityLMTK1 Polyclonal Antibody detects endogenous levels of protein.
Gene NameAATK AATYK KIAA0641 LMR1 LMTK1
Protein NameSerine/threonine-protein kinase LMTK1 (Apoptosis-associated tyrosine kinase) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (Lemur tyrosine kinase 1) (p35-binding protein) (p35BP)
Other Name
SpeciesHuman
Gene ID9625
UniprotQ6ZMQ8,
Species.1Mouse
Gene ID.1
Uniprot.1Q80YE4
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationMembrane; Single-pass type I membrane protein . Cytoplasm . Cytoplasm, perinuclear region . Predominantly perinuclear.
Tissue ExpressionExpressed in brain.
Signaling_pathway
Research Areas
FunctionCatalytic activity:ATP + a protein = ADP + a phosphoprotein.,Function:May be involved in neuronal differentiation.,induction:Up-regulated during apoptosis.,PTM:Autophosphorylated. Phosphorylated by CDK5.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Contains 1 protein kinase domain.,subcellular location:Predominantly perinuclear.,subunit:Interacts with CDK5.,tissue specificity:Expressed in brain.,
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