LPPR4 Polyclonal Antibody
Ucallm_WP2429-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene belongs to the lipid phosphate phosphatase (LPP) family. LPPs catalyze the dephosphorylation of a number of bioactive lipid mediators that regulate a variety of cell functions. This protein is specifically expressed in neurons. It is located in the membranes of outgrowing axons and has been shown to be important for axonal outgrowth during development and regenerative sprouting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009],
Specifications
| Size | 50μL/100μL |
| Target | LPPR4 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 83kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein.AA55-80 |
| Specificity | LPPR4 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | LPPR4 KIAA0455 PRG1 |
| Protein Name | Lipid phosphate phosphatase-related protein type 4 (Brain-specific phosphatidic acid phosphatase-like protein 1) (Plasticity-related gene 1 protein) (PRG-1) |
| Other Name | |
| Species | Human |
| Gene ID | 9890 |
| Uniprot | Q7Z2D5, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q7TME0, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q7TMB7 |
| Cellular Localization | Cell junction, synapse, postsynaptic density membrane; Multi-pass membrane protein . |
| Tissue Expression | Expressed by glutamatergic neurons (at protein level). |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalytic activity:A 3-sn-phosphatidate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.,Function:Hydrolyzes lysophosphatidic acid (LPA). Facilitates axonal outgrowth during development and regenerative sprouting. In the outgrowing axons acts as an ecto-enzyme and attenuates phospholipid-induced axon collapse in neurons and facilitates outgrowth in the hippocampus.,similarity:Belongs to the PA-phosphatase related phosphoesterase family.,tissue specificity:Specifically expressed in neurons., |
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