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LRIG1 Polyclonal Antibody
Ucallm_WP3276-50
Price range: $268.00 through $328.00
Product details
Background:
domain:The LRRs and the Ig-domains are each sufficient for EGFR/ERBB1 binding. This interaction is abolished only when these two domains are deleted., function:Act as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation., induction:By EGF., similarity:Contains 17 LRR (leucine-rich) repeats., similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains., subunit:Interacts with EGFR/ERBB1, ERBB2, ERBB3 and ERBB4., tissue specificity:Widely expressed.,
Specifications
| Size | 50μL/100μL |
| Target | LRIG1 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 120kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | LRIG1 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | LRIG1 LIG1 |
| Protein Name | Leucine-rich repeats and immunoglobulin-like domains protein 1 (LIG-1) |
| Other Name | |
| Species | Human |
| Gene ID | 26018 |
| Uniprot | Q96JA1, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P70193 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein . |
| Tissue Expression | Widely expressed. |
| Signaling_pathway | |
| Research Areas | |
| Function | Domain:The LRRs and the Ig-domains are each sufficient for EGFR/ERBB1 binding. This interaction is abolished only when these two domains are deleted.,Function:Act as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.,induction:By EGF.,similarity:Contains 17 LRR (leucine-rich) repeats.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Interacts with EGFR/ERBB1, ERBB2, ERBB3 and ERBB4.,tissue specificity:Widely expressed., |
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