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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/LT-β Polyclonal Antibody
SKU: WP13033 Categories: ,

LT-β Polyclonal Antibody

Ucallm_WP13033-50

Price range: $268.00 through $328.00

SKU: WP13033-100
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Product details

Background:

Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetLT-β
ReactivityHuman, Mouse
ApplicationsWB, IF, ELISA
MW(Calculated)
MW(Observed)22kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human TNFC. AA range:181-230
SpecificityLT-β Polyclonal Antibody detects endogenous levels of LT-β protein.
Gene NameLTB
Protein NameLymphotoxin-beta
Other NameLTB; / TNFC; / TNFSF3; / Lymphotoxin-beta; / LT-beta; / Tumor necrosis factor C; / TNF-C; / Tumor necrosis factor ligand superfamily member 3
SpeciesHuman
Gene ID4050
UniprotQ06643,
Species.1Mouse
Gene ID.116994
Uniprot.1P41155
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationMembrane; Single-pass type II membrane protein .
Tissue ExpressionSpleen and thymus.
Signaling_pathwayHuman Diseases >> Immune disease >> Rheumatoid arthritis;Environmental Information Processing >> Signal transduction >> NF-kappa B signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction
Research Areas>>Cytokine-cytokine receptor interaction; / >>NF-kappa B signaling pathway; / >>Rheumatoid arthritis
FunctionFunction:Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional.,similarity:Belongs to the tumor necrosis factor family.,subunit:Heterotrimer of either two LTB and one LTA subunits or (less prevalent) one LTB and two LTA subunits.,tissue specificity:Spleen and thymus.,
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