Price range: $268.00 through $328.00
Background:
This gene encodes a member of the BTB-kelch superfamily. Initially described as a putative transcriptional regulator based on weak homology to members of the basic leucine zipper-like family, the encoded protein subsequently has been shown to localize exclusively to the Golgi network where it may help stabilize the Gogli complex. Deletion of this gene may be associated with DiGeorge syndrome. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | LZTR1 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 92kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 310-390 |
| Specificity | LZTR1 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | LZTR1 TCFL2 |
| Protein Name | Leucine-zipper-like transcriptional regulator 1 (LZTR-1) |
| Other Name | |
| Species | Human |
| Gene ID | 8216 |
| Uniprot | Q8N653, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9CQ33 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Endomembrane system . Recycling endosome . Golgi apparatus . |
| Tissue Expression | Brain,Duodenal adenocarcinoma,Fetal brain, |
| Signaling_pathway | |
| Research Areas | |
| Function | developmental stage:Expressed in fetal brain, heart, kidney, liver and lung.,Disease:May play a part in the etiology of the velocardiofacial/DiGeorge syndrome (VCFS/DGS), a developmental disorder characterized by structural and functional palate anomalies, conotruncal cardiac malformations, immunodeficiency, hypocalcemia, and typical facial anomalies. Most cases result from a deletion of chromosome 22q11.2 (the DiGeorge syndrome chromosome region, or DGCR).,Function:Probable transcriptional regulator that may play a crucial role in embryogenesis.,similarity:Contains 2 BTB (POZ) domains.,similarity:Contains 6 Kelch repeats., |
