SKU: WP13068 Categories: ,

MAP-2 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP13068-100
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Product details

Background:

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010],

Specifications

Size50μL/100μL
TargetMAP-2
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)280kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human MAP2. AA range:14-63
SpecificityMAP2 Polyclonal Antibody detects endogenous levels of MAP2 protein.
Gene NameMAP2
Protein NameMicrotubule-associated protein 2
Other NameMAP2; / Microtubule-associated protein 2; / MAP-2
SpeciesHuman
Gene ID4133
UniprotP11137,
Species.1Mouse
Gene ID.1
Uniprot.1P20357,
Species.2Rat
Gene ID.2
Uniprot.2P15146
Cellular LocalizationCytoplasm, cytoskeleton . Cell projection, dendrite .
Tissue ExpressionBrain,Brain cortex,Epithelium,Pancreas,Testis,
Signaling_pathway
Research Areas
FunctionAlternative products:Additional isoforms seem to exist,Function:The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.,PTM:MAP2A/c is phosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 3 Tau/MAP repeats.,similarity:Contains 4 Tau/MAP repeats.,
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