MAP2 [N-term] mouse mAb
Ucallm_WM0756-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010],
Specifications
| Size | 50μL/100μL |
| Target | MAP-2 |
| Reactivity | Human, Mouse |
| Applications | WB, IP, ICC |
| MW(Calculated) | |
| MW(Observed) | 300kD |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:1000; ICC 1:150 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 4D3 |
| Immunogen | Purified recombinant human MAP2 (N-terminus) protein fragments expressed in E.coli |
| Specificity | This antibody detects endogenous levels of MAP2 (N-terminus) and does not cross-react with related proteins. |
| Gene Name | map2 |
| Protein Name | |
| Other Name | DKFZp686I2148; / Dendrite specific MAP; / DKFZp686I2148; / MAP 2; / MAP dendrite specific; / MAP-2; / MAP2; / MAP2A; / MAP2B; / MAP2C; / Microtubule associated protein 2; / Microtubule-associated protein 2; / Mtap 2; / MTAP2_HUMAN. |
| Species | Human |
| Gene ID | 4133 |
| Uniprot | P11137, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P20357 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm, cytoskeleton . Cell projection, dendrite . |
| Tissue Expression | Brain,Brain cortex,Epithelium,Pancreas,Testis, |
| Signaling_pathway | |
| Research Areas | |
| Function | Alternative products:Additional isoforms seem to exist,Function:The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.,PTM:MAP2A/c is phosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 3 Tau/MAP repeats.,similarity:Contains 4 Tau/MAP repeats., |
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