Name: Matriptase Polyclonal Antibody
SKU: WP13091
Price: 268 USD
Availability: InStock

Matriptase Polyclonal Antibody

Ucallm_WP13091-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WP13091-100

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Product details

Background:

The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	Matriptase
Reactivity	Human, Mouse
Applications	WB, IF, ELISA
MW(Calculated)
MW(Observed)	95kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human ST14. AA range:10-59
Specificity	Matriptase Polyclonal Antibody detects endogenous levels of Matriptase protein.
Gene Name	ST14
Protein Name	Suppressor of tumorigenicity 14 protein
Other Name	ST14; / PRSS14; / SNC19; / TADG15; / Suppressor of tumorigenicity 14 protein; / Matriptase; / Membrane-type serine protease 1; / MT-SP1; / Prostamin; / Serine protease 14; / Serine protease TADG-15; / Tumor-associated differentially-expressed gene 15 protein
Species	Human
Gene ID	6768
Uniprot	Q9Y5Y6,
Species.1	Mouse
Gene ID.1
Uniprot.1	P56677
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Membrane; Single-pass type II membrane protein .
Tissue Expression	Blood,Colon,Milk,Muscle,Prostate,
Signaling_pathway	Human Diseases >> Cancer: overview >> MicroRNAs in cancer
Research Areas	>>MicroRNAs in cancer
Function	Catalytic activity:Cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position.,Disease:Defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH) [MIM:610765]. ARIH is a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of hair.,Function:Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 2 CUB domains.,similarity:Contains 4 LDL-receptor class A domains.,subunit:Interacts with CDCP1. May interact with TMEFF1.,