SKU: WP15776 Categories: ,

MBL-C Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP15776-100
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Product details

Background:

This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetMBL-C
ReactivityHuman, Mouse
ApplicationsWB, IHC
MW(Calculated)
MW(Observed)27kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; IHC 1:50-300 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthetic peptide from human protein at AA range: 21-70
SpecificityThe antibody detects endogenous MBL-C protein
Gene NameMBL2 COLEC1 MBL
Protein Namemannose-binding lectin (protein C) 2, soluble (opsonic defect)
Other NameMBL2; / COLEC1; / MBL; / Mannose-binding protein C; / MBP-C; / Collectin-1; / MBP1; / Mannan-binding protein; / Mannose-binding lectin
SpeciesHuman
Gene ID4153
UniprotP11226,
Species.1Mouse
Gene ID.117195
Uniprot.1P41317
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationSecreted .
Tissue ExpressionPlasma protein produced mainly in the liver.
Signaling_pathwayCellular Processes >> Transport and catabolism >> Phagosome;Organismal Systems >> Immune system >> Complement and coagulation cascades
Research Areas>>Phagosome; / >>Complement and coagulation cascades; / >>Staphylococcus aureus infection; / >>Coronavirus disease - COVID-19
FunctionDisease:Genetic variations in MBL2 are associated with susceptibility to hepatitis B virus infection (HBV infection) [MIM:610424]. Approximately one third of all cases of cirrhosis and half of all cases of hepatocellular carcinoma can be attributed to chronic HBV infection. HBV infection may result in subclinical or asymptomatic infection, acute self-limited hepatitis, or fulminant hepatitis requiring liver transplantation.,Disease:There is an association between low levels of MBL2 and a defect of opsonization which results in susceptibility to frequent and chronic infections.,Function:Binds mannose and N-acetylglucosamine in a calcium-dependent manner. Is capable of host defense against pathogens, by activating the classical complement pathway independently of the antibody.,online information:Mannose-binding protein,similarity:Contains 1 C-type lectin domain.,similarity:Contains 1 collagen-like domain.,subunit:Oligomeric complex of 6 set of homotrimers. Interacts with MASP1 and MASP2; the interaction is calcium-dependent.,
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