SKU: WP2951 Categories: ,

MCHR1 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP2951-100
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Product details

Background:

melanin concentrating hormone receptor 1(MCHR1) Homo sapiens The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetMCHR1
ReactivityHuman, Mouse, Rat
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)46kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from part region of human protein
SpecificityMCHR1 Polyclonal Antibody detects endogenous levels of protein.
Gene NameMCHR1 GPR24 SLC1
Protein NameMelanin-concentrating hormone receptor 1 (MCH receptor 1) (MCH-R1) (MCHR-1) (G-protein coupled receptor 24) (MCH-1R) (MCH1R) (MCHR) (SLC-1) (Somatostatin receptor-like protein)
Other Name
SpeciesHuman
Gene ID2847
UniprotQ99705,
Species.1Mouse
Gene ID.1
Uniprot.1Q8JZL2,
Species.2Rat
Gene ID.2
Uniprot.2P97639
Cellular LocalizationCell membrane; Multi-pass membrane protein.
Tissue ExpressionHighest level in brain, particularly in the frontal cortex and hypothalamus, lower levels in the liver and heart.
Signaling_pathway
Research Areas>>Neuroactive ligand-receptor interaction
FunctionCaution:It is uncertain whether Met-1, Met-6 or Met-70 is the initiator.,Function:Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with NCDN.,tissue specificity:Highest level in brain, particularly in the frontal cortex and hypothalamus, lower levels in the liver and heart.,
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