Price range: $268.00 through $328.00
Background:
This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],
| Size | 50μL/100μL |
| Target | MEK Kinase-6 |
| Reactivity | Human, Mouse |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | 143kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MAP3K6. AA range:281-330 |
| Specificity | MEK Kinase-6 Polyclonal Antibody detects endogenous levels of MEK Kinase-6 protein. |
| Gene Name | MAP3K6 |
| Protein Name | Mitogen-activated protein kinase kinase kinase 6 |
| Other Name | MAP3K6; / ASK2; / MAPKKK6; / MEKK6; / Mitogen-activated protein kinase kinase kinase 6; / Apoptosis signal-regulating kinase 2 |
| Species | Human |
| Gene ID | 9064 |
| Uniprot | O95382, |
| Species.1 | Mouse |
| Gene ID.1 | 53608 |
| Uniprot.1 | Q9WTR2 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | intracellular, |
| Tissue Expression | Brain,PCR rescued clones,Skin, |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> MAPK signaling pathway |
| Research Areas | >>MAPK signaling pathway |
| Function | Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-806. Catalytically active only when complexed with MAP3K5, with MAP3K5 supporting the stability and the active configuration of MAP3K6 and MAP3K6 activating MAP3K5 by direct phosphorylation.,Function:Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Binds both upstream activators and downstream substrates in multimolecular complexes., |
