SKU: WP2465 Categories: ,

MFGM Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP2465-100
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Product details

Background:

This gene encodes a preproprotein that is proteolytically processed to form multiple protein products. The major encoded protein product, lactadherin, is a membrane glycoprotein that promotes phagocytosis of apoptotic cells. This protein has also been implicated in wound healing, autoimmune disease, and cancer. Lactadherin can be further processed to form a smaller cleavage product, medin, which comprises the major protein component of aortic medial amyloid (AMA). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015],

Specifications

Size50μL/100μL
TargetMFGM
ReactivityHuman, Mouse, Rat
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)42kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from part region of human protein
SpecificityMFGM Polyclonal Antibody detects endogenous levels of protein.
Gene NameMFGE8
Protein NameLactadherin (Breast epithelial antigen BA46) (HMFG) (MFGM) (Milk fat globule-EGF factor 8) (MFG-E8) (SED1) [Cleaved into: Lactadherin short form; Medin]
Other Name
SpeciesHuman
Gene ID4240
UniprotQ08431,
Species.1Mouse
Gene ID.1
Uniprot.1P21956,
Species.2Rat
Gene ID.2
Uniprot.2P70490
Cellular LocalizationMembrane; Peripheral membrane protein . Secreted . Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Peripheral membrane protein . Located in the acrosomal region of zona-pellucida bound sperm. .
Tissue ExpressionMammary epithelial cell surfaces and aortic media. Overexpressed in several carcinomas.
Signaling_pathway
Research Areas
FunctionFunction:Medin is the main constituent of aortic medial amyloid.,Function:Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Binds specifically to rotavirus and inhibits its replication.,PTM:Medin has a ragged N-terminus with minor species starting at Pro-264 and Gly-273.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 F5/8 type C domain.,similarity:Contains 2 F5/8 type C domains.,similarity:Contains 3 F5/8 type C domains.,tissue specificity:Mammary epithelial cell surfaces and aortic media. Overexpressed in several carcinomas.,
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