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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/MGST3 Polyclonal Antibody
SKU: WP13162 Categories: ,

MGST3 Polyclonal Antibody

Ucallm_WP13162-50

Price range: $268.00 through $328.00

SKU: WP13162-100
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Product details

Background:

This gene encodes a member of the MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) protein family. Members of this family are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.[provided by RefSeq, May 2011],

Specifications

Size50μL/100μL
TargetMGST3
ReactivityHuman, Mouse
ApplicationsIHC, IF, ELISA
MW(Calculated)17kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human MGST3. AA range:8-57
SpecificityMGST3 Polyclonal Antibody detects endogenous levels of MGST3 protein.
Gene NameMGST3
Protein NameMicrosomal glutathione S-transferase 3
Other NameMGST3; / Microsomal glutathione S-transferase 3; / Microsomal GST-3; / Microsomal GST-III
SpeciesHuman
Gene ID4259
UniprotO14880,
Species.1Mouse
Gene ID.166447
Uniprot.1Q9CPU4
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationEndoplasmic reticulum membrane; Multi-pass membrane protein . Microsome membrane; Multi-pass membrane protein . Microsome membrane; Lipid-anchor . Membrane .
Tissue ExpressionPredominantly expressed in heart, skeletal muscle, and adrenal cortex. Also found in brain, placenta, liver, kidney, pancreas, thyroid, testis and ovary. Almost absent in lung, thymus and peripheral blood leukocytes.
Signaling_pathwayHuman Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: specific types >> Hepatocellular carcinoma
Research Areas>>Glutathione metabolism; / >>Metabolism of xenobiotics by cytochrome P450; / >>Drug metabolism - cytochrome P450; / >>Drug metabolism - other enzymes; / >>Metabolic pathways; / >>Platinum drug resistance; / >>Pathways in cancer; / >>Chemical carcinogenesis - DNA adducts; / >>Chemical carcinogenesis - receptor activation; / >>Chemical carcinogenesis - reactive oxygen species; / >>Hepatocellular carcinoma; / >>Fluid shear stress and atherosclerosis
FunctionCatalytic activity:RX + glutathione = HX + R-S-glutathione.,Function:Also functions as a glutathione peroxidase.,similarity:Belongs to the MAPEG family.,tissue specificity:Predominantly expressed in heart, skeletal muscle, and adrenal cortex. Also found in brain, placenta, liver, kidney, pancreas, thyroid, testis and ovary. Almost absent in lung, thymus and peripheral blood leukocytes.,
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