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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/Mi2-β Polyclonal Antibody
SKU: WP13163 Categories: ,

Mi2-β Polyclonal Antibody

Ucallm_WP13163-50

Price range: $268.00 through $328.00

SKU: WP13163-100
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Product details

Background:

The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014],

Specifications

Size50μL/100μL
TargetCHD4
ReactivityHuman, Mouse
ApplicationsIHC, IF, ELISA
MW(Calculated)218kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human CHD4. AA range:571-620
SpecificityMi2-β Polyclonal Antibody detects endogenous levels of Mi2-β protein.
Gene NameCHD4
Protein NameChromodomain-helicase-DNA-binding protein 4
Other NameCHD4; / Chromodomain-helicase-DNA-binding protein 4; / CHD-4; / ATP-dependent helicase CHD4; / Mi-2 autoantigen 218 kDa protein; / Mi2-beta
SpeciesHuman
Gene ID1108
UniprotQ14839,
Species.1Mouse
Gene ID.1107932
Uniprot.1Q6PDQ2
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationNucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Associates with centrosomes in interphase. .
Tissue ExpressionEpithelium,Pancreas,Skin,Uterus,
Signaling_pathwayGenetic Information Processing >> Chromosome >> ATP-dependent chromatin remodeling
Research Areas>>Human papillomavirus infection; / >>Viral carcinogenesis
FunctionDisease:One of the main antigens reacting with anti-MI-2 positive sera of dermatomyositis.,Function:Probable transcription regulator.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the SNF2/RAD54 helicase family.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,similarity:Contains 2 chromo domains.,similarity:Contains 2 PHD-type zinc fingers.,subunit:Central component of the nucleosome remodeling and histone deacetylase (NuRD) repressor complex. Interacts with TRIM27. Part of a complex containing ATR and HDAC2. Interacts with KLF1; the interaction depends on sumoylation of KLF1, and leads to its transcriptional repression.,
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