SKU: WP13193 Categories: ,

MLK4 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP13193-100
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Product details

Background:

catalytic activity:ATP + a protein = ADP + a phosphoprotein., cofactor:Magnesium., enzyme regulation:Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation., function:Activates the JUN N-terminal pathway., PTM:Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation., similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily., similarity:Contains 1 protein kinase domain., similarity:Contains 1 SH3 domain., subunit:Homodimer.,

Specifications

Size50μL/100μL
TargetMLK4
ReactivityHuman, Mouse
ApplicationsWB, ELISA, IHC
MW(Calculated)
MW(Observed)110kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human MAP3KL4. AA range:631-680
SpecificityMLK4 Polyclonal Antibody detects endogenous levels of MLK4 protein.
Gene NameMLK4 MAP3KL4
Protein NameMitogen-activated protein kinase kinase kinase MLK4
Other NameMLK4; / KIAA1804; / Mitogen-activated protein kinase kinase kinase MLK4; / Mixed lineage kinase 4
SpeciesHuman
Gene ID84451
UniprotQ5TCX8,
Species.1Mouse
Gene ID.1
Uniprot.1Q8VDG6
Species.2
Gene ID.2
Uniprot.2
Cellular Localizationintracellular,
Tissue ExpressionBrain,Heart,
Signaling_pathwayEnvironmental Information Processing >> Signal transduction >> MAPK signaling pathway
Research Areas
FunctionCatalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation.,Function:Activates the JUN N-terminal pathway.,PTM:Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH3 domain.,subunit:Homodimer.,
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