Price range: $268.00 through $328.00
Background:
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP24 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008],
| Size | 50μL/100μL |
| Target | USP24 |
| Reactivity | Human, Mouse |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | 211kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human USP24. AA range:21-70 |
| Specificity | USP24 Polyclonal Antibody detects endogenous levels of USP24 protein. |
| Gene Name | USP24 |
| Protein Name | Ubiquitin carboxyl-terminal hydrolase 24 |
| Other Name | USP24; / KIAA1057; / Ubiquitin carboxyl-terminal hydrolase 24; / Deubiquitinating enzyme 24; / Ubiquitin thioesterase 24; / Ubiquitin-specific-processing protease 24 |
| Species | Human |
| Gene ID | 23358 |
| Uniprot | Q9UPU5, |
| Species.1 | Mouse |
| Gene ID.1 | 329908 |
| Uniprot.1 | B1AY13 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | cytoplasm, |
| Tissue Expression | Brain,Epithelium,Placenta,Platelet,T-cell, |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,Function:Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the peptidase C19 family.,similarity:Contains 1 UBA domain., |
