MLXPL rabbit pAb
Ucallm_WP16663-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015],
Specifications
| Size | 50μL/100μL |
| Target | MLXPL |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA, IHC |
| MW(Calculated) | 94kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human MLXPL AA range: 303-353 |
| Specificity | This antibody detects endogenous levels of MLXPL at Human/Mouse/Rat |
| Gene Name | MLXIPL BHLHD14 MIO WBSCR14 |
| Protein Name | MLXPL |
| Other Name | |
| Species | Human |
| Gene ID | 51085 |
| Uniprot | Q9NP71, |
| Species.1 | Mouse |
| Gene ID.1 | 58805 |
| Uniprot.1 | Q99MZ3, |
| Species.2 | Rat |
| Gene ID.2 | 171078 |
| Uniprot.2 | Q8VIP2 |
| Cellular Localization | Nucleus. |
| Tissue Expression | Expressed in liver, heart, kidney, cerebellum and intestinal tissues. |
| Signaling_pathway | |
| Research Areas | >>Insulin resistance; / >>Non-alcoholic fatty liver disease |
| Function | Disease:Haploinsufficiency of WBSCR14 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS) [MIM:194050]. WBS is a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23.,Function:Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Binds DNA as a heterodimer with TCFL4/MLX.,tissue specificity:Expressed in liver, heart, kidney, cerebellum and intestinal tissues., |
Please login to post questions
Related products
