Name: MMEL1 Polyclonal Antibody
SKU: WP2535
Price: 268 USD
Availability: InStock

MMEL1 Polyclonal Antibody

Ucallm_WP2535-50

Price range: $268.00 through $328.00

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50μl

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SKU: WP2535-100

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Product details

Background:

The protein encoded by this gene is a member of the neutral endopeptidase (NEP) or membrane metallo-endopeptidase (MME) family. Family members play important roles in pain perception, arterial pressure regulation, phosphate metabolism and homeostasis. This protein is a type II transmembrane protein and is thought to be expressed as a secreted protein. This gene is expressed mainly in testis with weak expression in the brain, kidney, and heart. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	MMEL1
Reactivity	Human, Mouse, Rat
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	85kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-2000; ELISA 1:5000-20000
Formulation	Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from part region of human protein
Specificity	MMEL1 Polyclonal Antibody detects endogenous levels of protein.
Gene Name	MMEL1 MELL1 MMEL2 NEP2
Protein Name	Membrane metallo-endopeptidase-like 1 (Membrane metallo-endopeptidase-like 2) (NEP2(m)) (Neprilysin II) (NEPII) (Neprilysin-2) (NEP2) (NL2) [Cleaved into: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))]
Other Name
Species	Human
Gene ID	79258
Uniprot	Q495T6,
Species.1	Mouse
Gene ID.1
Uniprot.1	Q9JLI3,
Species.2	Rat
Gene ID.2
Uniprot.2	P0C1T0
Cellular Localization	Membrane; Single-pass type II membrane protein. Secreted. A secreted form produced by proteolytic cleavage also exists. .
Tissue Expression	Predominantly expressed in testis. Weakly expressed in brain, kidney and heart.
Signaling_pathway
Research Areas
Function	Catalytic activity:Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'.,cofactor:Binds 1 zinc ion per subunit.,enzyme regulation:Inhibited by thiorphan and phosphoramidon.,Function:Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificiy with MME and cleaves peptides at the same amide bond.,PTM:N-glycosylated.,similarity:Belongs to the peptidase M13 family.,subcellular location:A secreted form produced by proteollytic cleavage also exists.,tissue specificity:Predominantly expressed in testis. Weakly expressed in brain, kidney and heart.,

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MMEL1 Polyclonal Antibody

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MMEL1 Polyclonal Antibody

Product details

Specifications

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