MMEL1 Polyclonal Antibody
Ucallm_WP2535-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a member of the neutral endopeptidase (NEP) or membrane metallo-endopeptidase (MME) family. Family members play important roles in pain perception, arterial pressure regulation, phosphate metabolism and homeostasis. This protein is a type II transmembrane protein and is thought to be expressed as a secreted protein. This gene is expressed mainly in testis with weak expression in the brain, kidney, and heart. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | MMEL1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 85kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | MMEL1 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | MMEL1 MELL1 MMEL2 NEP2 |
| Protein Name | Membrane metallo-endopeptidase-like 1 (Membrane metallo-endopeptidase-like 2) (NEP2(m)) (Neprilysin II) (NEPII) (Neprilysin-2) (NEP2) (NL2) [Cleaved into: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))] |
| Other Name | |
| Species | Human |
| Gene ID | 79258 |
| Uniprot | Q495T6, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9JLI3, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P0C1T0 |
| Cellular Localization | Membrane; Single-pass type II membrane protein. Secreted. A secreted form produced by proteolytic cleavage also exists. . |
| Tissue Expression | Predominantly expressed in testis. Weakly expressed in brain, kidney and heart. |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalytic activity:Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'.,cofactor:Binds 1 zinc ion per subunit.,enzyme regulation:Inhibited by thiorphan and phosphoramidon.,Function:Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificiy with MME and cleaves peptides at the same amide bond.,PTM:N-glycosylated.,similarity:Belongs to the peptidase M13 family.,subcellular location:A secreted form produced by proteollytic cleavage also exists.,tissue specificity:Predominantly expressed in testis. Weakly expressed in brain, kidney and heart., |
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