MOT4 Polyclonal Antibody
Ucallm_WP16038-50
Price range: $268.00 through $328.00
Product details
Background:
Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]).[supplied by OMIM, Mar 2008],
Specifications
| Size | 50μL/100μL |
| Target | MCT4 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA, IHC |
| MW(Calculated) | |
| MW(Observed) | 50kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human MOT4 Polyclonal |
| Specificity | This antibody detects endogenous levels of MOT4. |
| Gene Name | SLC16A3 MCT4 |
| Protein Name | Monocarboxylate transporter 4 (MCT 4) (Solute carrier family 16 member 3) |
| Other Name | Monocarboxylate transporter 4; / MCT 4; / Solute carrier family 16 member 3 |
| Species | Human |
| Gene ID | 9123 |
| Uniprot | O15427, |
| Species.1 | Mouse |
| Gene ID.1 | 80879 |
| Uniprot.1 | P57787, |
| Species.2 | Rat |
| Gene ID.2 | 80878 |
| Uniprot.2 | O35910 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. |
| Tissue Expression | Highly expressed in skeletal muscle. |
| Signaling_pathway | Human Diseases >> Cancer: overview >> Central carbon metabolism in cancer |
| Research Areas | >>Central carbon metabolism in cancer |
| Function | Function:Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate.,similarity:Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.,tissue specificity:Highly expressed in skeletal muscle., |
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