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Home/Reagents/Antibody/Primary antibody/Monoclonal Antibody/Mouse mAb/Myeloperoxidase [MPO] [ABT-MPO] mouse mAb
SKU: WM1434 Categories: ,

Myeloperoxidase [MPO] [ABT-MPO] mouse mAb

Ucallm_WM1434-50

Price range: $268.00 through $328.00

SKU: WM1434-50
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Product details

Background:
Myeloperoxidase (MPO) is an important enzyme in the process of phagocytosis and lysis of exosomes by granulocytes. It is a specific marker of bone marrow cells. MPO is strongly expressed in normal lymphoid tissues and various myeloid cell hyperplasia, but not in erythroid precursors, lymphoid cells, prokaryotic cells, mast cells, plasma cells, various epithelial tumors and sarcomas. It is mainly used for the differential diagnosis of myeloid cell tumor and lymphoid cell tumor.

Specifications

Size50μL/100μL
TargetMyeloperoxidase
ReactivityHuman
ApplicationsIHC, WB, IF, ELISA
MW(Calculated)84kD
MW(Observed)84kD,60kD
Host SpeciesMouse
IsotypeIgG2a,Kappa
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
PurificationRecombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone NumberRMM-MPO
ImmunogenSynthesized peptide derived from human protein. AA range:350-450
SpecificityThe antibody can specifically recognize human Myeloperoxidase protein.
Gene NameMPO
Protein NameMyeloperoxidase(MPO)
Other Name84 kDa myeloperoxidase; / 89 kDa myeloperoxidase; / EC1.11.2.2; / fj80f04; / MPO; / mpx; / myeloid-specific peroxidase; / Myeloperoxidase; / Myeloperoxidase heavy chain; / Myeloperoxidase light chain; / PERM_HUMAN; / wu:fj80f04
SpeciesHuman
Gene ID4353
UniprotP05164
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCytoplasmic
Tissue ExpressionLeukemia,Leukocyte,Liver,Plasma,Saliva,
Signaling_pathwayCellular Processes >> Transport and catabolism >> Phagosome;Organismal Systems >> Immune system >> Neutrophil extracellular trap formation;Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer;Human Diseases >> Cancer: specific types >> Acute myeloid leukemia
Research Areas>>Drug metabolism - other enzymes; / >>Phagosome; / >>Neutrophil extracellular trap formation; / >>Transcriptional misregulation in cancer; / >>Acute myeloid leukemia
FunctionCatalytic activity:Cl(-) + H(2)O(2) = HOCl + 2 H(2)O.,Catalytic activity:Donor + H(2)O(2) = oxidized donor + 2 H(2)O.,cofactor:Binds 1 calcium ion per heterodimer.,cofactor:Binds 1 heme B (iron-protoporphyrin IX) group covalently per heterodimer.,Disease:Defects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis.,Function:Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.,online information:MPO mutation db,online information:Myeloperoxidase entry,similarity:Belongs to the peroxidase family. XPO subfamily.,subunit:Tetramer of two light chains and two heavy chains.,
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