Price range: $268.00 through $328.00
Background:
Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | MYL2 |
| Reactivity | Human |
| Applications | WB, ELISA |
| MW(Calculated) | 19kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 15D7 |
| Immunogen | Purified recombinant fragment of MYL2 expressed in E. Coli. |
| Specificity | MYL2 Monoclonal Antibody detects endogenous levels of MYL2 protein. |
| Gene Name | MYL2 |
| Protein Name | Myosin regulatory light chain 2 ventricular/cardiac muscle isoform |
| Other Name | MYL2; / Myosin regulatory light chain 2; / ventricular/cardiac muscle isoform; / MLC-2; / MLC-2v |
| Species | Human |
| Gene ID | 4633 |
| Uniprot | P10916 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm, myofibril, sarcomere, A band . |
| Tissue Expression | Highly expressed in type I muscle fibers. |
| Signaling_pathway | Cellular Processes >> Cellular community - eukaryotes >> Focal adhesion;Cellular Processes >> Cellular community - eukaryotes >> Adherens junction;Cellular Processes >> Cellular community - eukaryotes >> Tight junction;Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton;Organismal Systems >> Immune system >> Leukocyte transendothelial migration;Organismal Systems >> Circulatory system >> Cardiac muscle contraction;Organismal Systems >> Circulatory system >> Adrenergic signaling in cardiomyocytes;Environmental Information Processing >> Signal transduction >> Apelin signaling pathway |
| Research Areas | >>Cardiac muscle contraction; / >>Adrenergic signaling in cardiomyocytes; / >>Apelin signaling pathway; / >>Focal adhesion; / >>Tight junction; / >>Leukocyte transendothelial migration; / >>Regulation of actin cytoskeleton; / >>Shigellosis; / >>Salmonella infection; / >>Hypertrophic cardiomyopathy; / >>Dilated cardiomyopathy |
| Function | Disease:Defects in MYL2 are the cause of cardiomyopathy familial hypertrophic type 10 (CMH10) [MIM:608758]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.,Disease:Defects in MYL2 are the cause of cardiomyopathy hypertrophic with mid-left ventricular chamber type 2 (MVC2) [MIM:608758]. MVC2 is a very rare variant of familial hypertrophic cardiomyopathy, characterized by mid-left ventricular chamber thickening.,miscellaneous:This chain binds calcium.,similarity:Contains 3 EF-hand domains.,subunit:Myosin is an hexamer of 2 heavy chains and 4 light chains., |
