U-Blot® NGAL Rabbit mAb
Ucallm_WR4964-50
Price range: $268.00 through $328.00
Product details
Background:This gene encodes a protein that belongs to the lipocalin family. Members of this family transport small hydrophobic molecules such as lipids, steroid hormones and retinoids. The protein encoded by this gene is a neutrophil gelatinase-associated lipocalin and plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores. The presence of this protein in blood and urine is an early biomarker of acute kidney injury. This protein is thought to be be involved in multiple cellular processes, including maintenance of skin homeostasis, and suppression of invasiveness and metastasis. Mice lacking this gene are more susceptible to bacterial infection than wild type mice. [provided by RefSeq, Sep 2015],
Specifications
| Size | 50μL/100μL |
| Target | NGAL |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 23kD |
| MW(Observed) | 23kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:1000-1:4000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1187R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | LCN2 HNL NGAL |
| Protein Name | NGAL |
| Other Name | Neutrophil gelatinase-associated lipocalin; / NGAL; / 25 kDa alpha-2-microglobulin-related subunit of MMP-9; / Lipocalin-2; / Oncogene 24p3; / Siderocalin LCN2; / p25 |
| Species | Human |
| Gene ID | 3934 |
| Uniprot | P80188 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Secreted . Cytoplasmic granule lumen . Cytoplasmic vesicle lumen . Upon binding to the SLC22A17 (24p3R) receptor, it is internalized (By similarity). Releases the bound iron in the acidic lumen of cytoplasmic vesicles (PubMed:12453413, PubMed:20581821). . |
| Tissue Expression | Detected in neutrophils (at protein level) (PubMed:7683678, PubMed:8298140). Expressed in bone marrow and in tissues that are prone to exposure to microorganism. High expression is found in bone marrow as well as in uterus, prostate, salivary gland, stomach, appendix, colon, trachea and lung. Not found in the small intestine or peripheral blood leukocytes. |
| Signaling_pathway | Organismal Systems >> Immune system >> IL-17 signaling pathway |
| Research Areas | >>IL-17 signaling pathway |
| Function | Function:Transport of small lipophilic substances .,similarity:Belongs to the calycin superfamily. Lipocalin family.,subunit:Forms a covalently linked, disulfide-bridged heterodimer with the 92 kDa type V collagenase (MMP-9).,tissue specificity:Expressed in bone marrow and in tissues that are prone to exposure to microorganism. High expression is found in bone marrow as well as in uterus, prostate, salivary gland, stomach, appendix, colon, trachea and lungs. Not found in the small intestine or peripheral blood leukocytes., |
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