Price range: $268.00 through $328.00
Background:
Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | NGFR p75 |
| Reactivity | Human |
| Applications | WB, IF, FC, ELISA |
| MW(Calculated) | 45kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IF 1:200-1:1000; Flow Cyt 1:200-1:400; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 3D2 |
| Immunogen | Purified recombinant fragment of human NGFR p75 expressed in E. Coli. |
| Specificity | NGFR p75 Monoclonal Antibody detects endogenous levels of NGFR p75 protein. |
| Gene Name | NGFR |
| Protein Name | Tumor necrosis factor receptor superfamily member 16 |
| Other Name | NGFR; / TNFRSF16; / Tumor necrosis factor receptor superfamily member 16; / Gp80-LNGFR; / Low affinity neurotrophin receptor p75NTR; / Low-affinity nerve growth factor receptor; / NGF receptor; / p75 ICD; / CD antigen CD271 |
| Species | Human |
| Gene ID | 4804 |
| Uniprot | P08138, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9Z0W1 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein . Perikaryon . Cell projection, growth cone . Cell projection, dendritic spine . |
| Tissue Expression | Brain, |
| Signaling_pathway | Cellular Processes >> Cell growth and death >> Apoptosis - multiple species;Organismal Systems >> Nervous system >> Neurotrophin signaling pathway;Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway;Environmental Information Processing >> Signal transduction >> Ras signaling pathway;Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction |
| Research Areas | >>MAPK signaling pathway; / >>Ras signaling pathway; / >>Rap1 signaling pathway; / >>Cytokine-cytokine receptor interaction; / >>PI3K-Akt signaling pathway; / >>Apoptosis - multiple species; / >>Neurotrophin signaling pathway; / >>Transcriptional misregulation in cancer |
| Function | Domain:Death domain is responsible for interaction with RANBP9.,Domain:The extracellular domain is responsible for interaction with NTRK1.,Function:Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.,PTM:N- and O-glycosylated.,PTM:O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc.,PTM:Phosphorylated on serine residues.,similarity:Contains 1 death domain.,similarity:Contains 4 TNFR-Cys repeats.,subunit:Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1 (By similarity). Interacts with LINGO1., |
