Name: NKX3.1 [ABT267] mouse mAb
SKU: WM1465
Price: 268 USD
Availability: InStock

NKX3.1 [ABT267] mouse mAb

Ucallm_WM1465-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WM1465-50

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Product details

Background:
NKX3.1 is a nuclear transcription factor and a negative regulator of the growth of prostatic epithelial cells. Its mRNA transcription level is regulated by androgens and plays an important role in the occurrence and differentiation of prostate organs and the maintenance of the function of mature organs. NKX3.1 has high sensitivity and specificity in benign prostatic hyperplasia and prostate cancer, and can be used as one of the specific markers to distinguish prostate cancer, benign prostatic hyperplasia and non prostate cancer. It is also expressed in mucous glands of testis, ureter and pulmonary bronchus.

Specifications

Size	50μL/100μL
Target	NKX3.1
Reactivity	Human
Applications	IHC, WB, IF, ELISA
MW(Calculated)	26kD
MW(Observed)	32kD
Host Species	Mouse
Isotype	IgG1,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RMM267
Immunogen	Synthesized peptide derived from human protein. AA range:1-100
Specificity	The antibody can specifically recognize human NKX3.1 protein.
Gene Name	NKX3-1 NKX3.1 NKX3A
Protein Name	Homeobox protein Nkx-3.1
Other Name	BAPX 2; / BAPX2; / Homeobox protein NK-3 homolog A; / Homeobox protein Nkx 3.1; / Homeobox protein Nkx-3.1; / Homeobox protein Nkx3.1; / NK homeobox; / Drosophila; / family 3 A; / NK homeobox family 3 A; / NK homeobox, family 3, member A; / NK3 homeobox 1; / NK3 transcription factor homolog A; / NK3 transcription factor related locus 1; / NKX 3; / Nkx 3.1; / NKX 3A; / NKX3 1; / NKX3; / Nkx3-1; / NKX3.1; / Nkx3.1, Mouse, homolog of; / NKX31_HUMAN; / NKX3A
Species	Human
Gene ID	4824
Uniprot	Q99801,
Species.1	Mouse
Gene ID.1
Uniprot.1	P97436
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Nuclear
Tissue Expression	Highly expressed in the prostate and, at a lower level, in the testis.
Signaling_pathway	Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: specific types >> Prostate cancer
Research Areas	>>Pathways in cancer; / >>Prostate cancer
Function	Alternative products:Additional isoforms seem to exist,Disease:NKX3-1 has been thought to be one of the target gene of the 8p21 loss of heterozygosity, common in prostate cancer, but neither disruption of the coding region of the gene, nor mutations have been found in prostate cancer.,Function:Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Could play an important role in regulating proliferation of glandular epithelium and in the formation of ducts in prostate.,induction:By androgens and, in the LNCAP cell line, by estrogens. Androgenic control may be lost in prostate cancer cells during tumor progression from an androgen-dependent to an androgen-independent phase.,similarity:Belongs to the NK-3 homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,subunit:Interacts with serum response factor (SRF) (By similarity). Interacts with SPDEF. Interacts with WDR77.,tissue specificity:Highly expressed in the prostate and, at a lower level, in the testis.,

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NKX3.1 [ABT267] mouse mAb

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NKX3.1 [ABT267] mouse mAb

Product details

Specifications

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