Price range: $268.00 through $328.00
Background:
The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Members of this family contain the POU domain, a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT.[supplied by OMIM, Jul 2010],
| Size | 50μL/100μL |
| Target | OCT1 |
| Reactivity | Human |
| Applications | WB, IHC, IF |
| MW(Calculated) | |
| MW(Observed) | 89kD |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IF 1:200; IHC 1:50-300 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol. |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 7G1 |
| Immunogen | Synthetic Peptide of 42644 |
| Specificity | The antibody detects endogenous Oct1 protein. |
| Gene Name | POU2F1 |
| Protein Name | POU domain class 2 transcription factor |
| Other Name | POU2F1; / OCT1; / OTF1; / POU domain; / class 2, transcription factor 1; / NF-A1; / Octamer-binding protein 1; / Oct-1; / Octamer-binding transcription factor 1; / OTF-1; / POU2F2; / OCT2; / OTF2; / POU domain, class 2, transcription factor 2; / Lymphoid-restricted im |
| Species | Human |
| Gene ID | 5451;5452 |
| Uniprot | P14859;P09086, |
| Species.1 | Mouse |
| Gene ID.1 | 18986;18987, |
| Uniprot.1 | |
| Species.2 | Rat |
| Gene ID.2 | 171068 |
| Uniprot.2 | P31503 |
| Cellular Localization | Nucleus. |
| Tissue Expression | Ubiquitous. Isoform 2 is lymphocyte-specific. |
| Signaling_pathway | |
| Research Areas | >>Herpes simplex virus 1 infection; / >>Lipid and atherosclerosis |
| Function | Function:Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR.,PTM:Phosphorylated by PRKDC.,similarity:Belongs to the POU transcription factor family. Class-2 subfamily.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 1 POU-specific domain.,subunit:Interacts with NR3C1, AR, PGR and HCFC1.,tissue specificity:Ubiquitous. Isoform 2 is lymphocyte-specific., |
