OLIG2 [PTR1315] mouse mAb
Ucallm_WM0688-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | OLIG2 |
| Reactivity | Human, Mouse |
| Applications | WB, IF, ELISA |
| MW(Calculated) | 32kD |
| MW(Observed) | 32kD |
| Host Species | Mouse |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RMMR1315 |
| Immunogen | Synthesized peptide derived from human protein.AA range:1-100 |
| Specificity | This antibody detects endogenous levels of OLIG2 protein. |
| Gene Name | olig2 |
| Protein Name | |
| Other Name | Basic domain helix loop helix protein class B 1; / Basic helix loop helix protein class B 1; / BHLHB; / bHLHB1; / bHLHe19; / Class B basic helix loop helix protein 1; / Class B basic helix-loop-helix protein 1; / class E basic helix loop helix protein 19; / Class E basic helix-loop-helix protein 19; / Human protein kinase C binding protein RACK17; / Olig2; / OLIG2_HUMAN; / Oligo2; / Oligodendrocyte lineage transcription factor 2; / Oligodendrocyte specific bHLH transcription factor 2; / Oligodendrocyte transcription factor 2; / OTTHUMP00000067569; / OTTHUMP00000067570; / PRKCBP2; / Protein kinase C binding protein 2; / Protein kinase C binding protein RACK17; / Protein kinase C-binding protein 2; / Protein kinase C-binding protein RACK17; / RACK17. |
| Species | Human |
| Gene ID | 10215 |
| Uniprot | Q13516, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9EQW6 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nuclear |
| Tissue Expression | Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable. |
| Signaling_pathway | |
| Research Areas | |
| Function | Disease:A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14; 21)(q11.2; q22) with TCRA.,Domain:The bHLH is essential for interaction with NKX2-2.,Function:Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development.,induction:By SHH. Also induced by NKX6-1 in the developing spinal cord, but not in the rostral hindbrain.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subcellular location:The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2.,subunit:Interacts with NKX2-2.,tissue specificity:Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable., |
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