Name: p120 catenin [ABT082] mouse mAb
SKU: WM1750
Price: 268 USD
Availability: InStock

Product details

Background:
catenin delta 1(CTNND1) Homo sapiens This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene. [provided by RefSeq, Dec 2010],

Specifications

Size	50μL/100μL
Target	p120 Catenin
Reactivity	Human, Mouse, Rat
Applications	IHC, ELISA
MW(Calculated)	108kD
MW(Observed)	108kD
Host Species	Mouse
Isotype	IgG2b,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:200-400; ELISA 1:500-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RMM082
Immunogen	Synthesized peptide derived from human p120 Catenin AA range: 600-700
Specificity	The antibody can specifically recognize human p120 catenin protein.
Gene Name	CTNND1 KIAA0384
Protein Name	Cadherin associated Src substrate; Cadherin-associated Src substrate; CAS; Catenin (cadherin associated protein) delta 1; Catenin delta 1; Catenin delta; Catenin delta-1; CTND1_HUMAN; CTNND 1; CTNND; CTNND1; delta 1 Catenin; KIAA0384; p120; P120 CAS; p120 catenin; P120 CTN; p120(cas); p120(ctn); P120CAS; P120CTN
Other Name	Cadherin associated Src substrate; / Cadherin-associated Src substrate; / CAS; / Catenin; / cadherin associated protein; / delta 1; / Catenin delta 1; / Catenin delta; / Catenin delta-1; / CTND1_HUMAN; / CTNND 1; / CTNND; / CTNND1; / delta 1 Catenin; / KIAA0384; / p120; / P120 CAS; / p120 catenin; / P120 CTN; / p120; / cas; / p120; / ctn; / P120CAS; / P120CTN
Species	Human
Gene ID	1500
Uniprot	O60716,
Species.1	Mouse
Gene ID.1
Uniprot.1	P30999
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cytoplasmic, Membranous
Tissue Expression	Breast/ Tonsil
Signaling_pathway	Cellular Processes >> Cellular community - eukaryotes >> Adherens junction;Organismal Systems >> Immune system >> Leukocyte transendothelial migration;Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway
Research Areas	>>Rap1 signaling pathway; / >>Adherens junction; / >>Leukocyte transendothelial migration
Function	Alternative products:Experimental confirmation may be lacking for some isoforms,Disease:May contribute to cell malignancy. Complete loss of expression was observed in approximately 10% of invasive ductal breast carcinomas investigated.,Domain:A possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are deleted.,Function:Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.,induction:Induced in vascular endothelium by wounding. This effect is potentiated by prior laminar shear stress, which enhances wound closure.,PTM:Phosphorylated.,similarity:Belongs to the beta-catenin family.,similarity:Contains 10 ARM repeats.,subcellular location:Interaction with GLIS2 promotes nuclear translocation.,subunit:Belongs to a multiprotein cell-cell adhesion complex that also contains E-cadherin, alpha-catenin, beta-catenin, and gamma-catenin. Binds to the C-terminal fragment of PSEN1 and mutually competes for E-cadherin. Interacts with ZBTB33. Interacts with GLIS2.,tissue specificity:Expressed in vascular endothelium.,

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p120 catenin [ABT082] mouse mAb

Product details

Specifications

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p120 catenin [ABT082] mouse mAb

Product details

Specifications

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