Name: PARL Monoclonal Antibody
SKU: WM0362
Price: 268 USD
Availability: InStock

PARL Monoclonal Antibody

Ucallm_WM0362-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WM0362-50

Enter the quantity you would like, or drag the panel to find the quantity and price that best for you

Bulk Quote Authorize OEM & ODM

Product details

Background:
This gene encodes a member of the rhomboid family of intramembrane serine proteases that is localized to the inner mitochondrial membrane. The encoded protein regulates mitochondrial remodeling and apoptosis through regulated substrate proteolysis. Proteolytic processing of the encoded protein results in the release of a small peptide, P-beta, which may transit to the nucleus. Mutations in this gene may be associated with Parkinson's disease. [provided by RefSeq, May 2016],

Specifications

Size	50μL/100μL
Target	PARL
Reactivity	Human
Applications	WB, ELISA
MW(Calculated)	42kD
MW(Observed)
Host Species	Mouse
Isotype
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	Affinity purification
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	11A2
Immunogen	Purified recombinant fragment of PARL (aa112-167) expressed in E. Coli.
Specificity	PARL Monoclonal Antibody detects endogenous levels of PARL protein.
Gene Name	PARL
Protein Name	Presenilins-associated rhomboid-like protein mitochondrial
Other Name	PARL; / PSARL; / Presenilins-associated rhomboid-like protein; / mitochondrial; / Mitochondrial intramembrane cleaving protease PARL
Species	Human
Gene ID	55486
Uniprot	Q9H300,
Species.1	Mouse
Gene ID.1
Uniprot.1	Q5XJY4
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Mitochondrion inner membrane; Multi-pass membrane protein .; [P-beta]: Nucleus . Translocated into the nucleus by an unknown mechanism (PubMed:17116872). .
Tissue Expression	Fetal liver,Lung,
Signaling_pathway
Research Areas
Function	Catalytic activity:Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.,Function:Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain.,PTM:P-beta is proteolytically processed (beta-cleavage) in a PARL-dependent manner. The cleavage is inhibited when residues Ser-65, Thr-69 and Ser-70 are all phosphorylated.,similarity:Belongs to the peptidase S54 family.,subcellular location:Translocated into the nucleus by an unknown mechanism.,subunit:Interacts with PSEN1 and PSEN2. Binds OPA1.,