PD-1 [ABT-PD1] mouse mAb
Ucallm_WM1619-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | PD1 |
| Reactivity | Human |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | 32kD |
| MW(Observed) | 56kD |
| Host Species | Mouse |
| Isotype | IgG1,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-400; IF 1:200-1:1000; ELISA 1:500-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RMM-PD1 |
| Immunogen | Synthesized peptide derived from human PD-1 AA range: 1-100 |
| Specificity | The antibody can specifically recognize human PD-1 protein. |
| Gene Name | PDCD1 PD1 |
| Protein Name | Programmed cell death protein 1 (Protein PD-1) (hPD-1) (CD antigen CD279) |
| Other Name | |
| Species | Human |
| Gene ID | 5133 |
| Uniprot | Q15116 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Membranous, Cytoplasmic |
| Tissue Expression | Placenta,Pooled tissue,Uterine cervix, |
| Signaling_pathway | Organismal Systems >> Immune system >> T cell receptor signaling pathway;Human Diseases >> Cancer: overview >> PD-L1 expression and PD-1 checkpoint pathway in cancer;Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules |
| Research Areas | >>Cell adhesion molecules; / >>T cell receptor signaling pathway; / >>PD-L1 expression and PD-1 checkpoint pathway in cancer |
| Function | developmental stage:Induced at programmed cell death.,Disease:Genetic variation in PDCD1 is associated with susceptibility to systemic lupus erythematosus type 2 (SLEB2) [MIM:605218]. Systemic lupus erythematosus is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.,Function:Possible cell death inducer, in association with other factors.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Monomer., |
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