Name: U-Blot® Peroxiredoxin 1 Rabbit mAb
SKU: WR4106
Price: 268 USD
Availability: InStock

U-Blot® Peroxiredoxin 1 Rabbit mAb

Various whole cell lysates were separated by 4-20% SDS-PAGE, and the primary antibody was used at 4°C, over night with a 1:2500 dilution . The Dylight 800-conjugated Goat anti-Rabbit antibody(Cat:WS0446) was used to detect the antibody.

WR4106 Various whole cell lysates were separated by 4-20% SDS-PAGE, and the primary antibody was used at 4°C, over night with a 1:2500 dilution . The Dylight 800-conjugated Goat anti-Rabbit antibody(Cat:WS0446) was used to detect the antibody.

Western blot analysis of lysates from HEK293 cells, using Peroxiredoxin 1 Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody (WS0002) was used to detect the antibody.

WR4106 Western blot analysis of lysates from HEK293 cells, using Peroxiredoxin 1 Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody (WS0002) was used to detect the antibody.

Price range: $268.00 through $328.00

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50μl

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SKU: WR4106-50

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Product details

Background:This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011],

Specifications

Size	50μL/100μL
Target	Prdx1
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, IP, ELISA
MW(Calculated)	22kD
MW(Observed)	26kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:200-1:1000; WB 1:1000-1:5000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200, / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM0201R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	PRDX1
Protein Name	Peroxiredoxin-1
Other Name	PRDX1; / PAGA; / PAGB; / TDPX2; / Peroxiredoxin-1; / Natural killer cell-enhancing factor A; / NKEF-A; / Proliferation-associated gene protein; / PAG; / Thioredoxin peroxidase 2; / Thioredoxin-dependent peroxide reductase 2
Species	Human
Gene ID	5052
Uniprot	Q06830,
Species.1	Mouse
Gene ID.1	18477
Uniprot.1	P35700,
Species.2	Rat
Gene ID.2	117254
Uniprot.2	Q63716
Cellular Localization	Cytoplasm
Tissue Expression	Brain,Cajal-Retzius cell,Fetal brain cortex,Urinary bladder,
Signaling_pathway	Cellular Processes >> Transport and catabolism >> Peroxisome
Research Areas	>>Peroxisome; / >>Amoebiasis
Function	Catalytic activity:2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH.,Function:Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).,induction:Constitutively expressed in most human cells; is induced to higher levels upon serum stimulation in untransformed and transformed cells.,miscellaneous:Inactivated upon oxidative stress by overoxidation of Cys-52 to Cys-SO(2)H and Cys-SO(3)H. Cys-SO(2)H is retroreduced to Cys-SOH after removal of H(2)O(2), while Cys-SO(3)H may be irreversibly oxidized.,miscellaneous:The active site is the redox-active Cys-52 oxidized to Cys-SOH. Cys-SOH rapidly reacts with Cys-173-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin.,PTM:Phosphorylated on Thr-90 during the M-phase, which leads to a more than 80% decrease in enzymatic activity.,similarity:Belongs to the ahpC/TSA family.,similarity:Contains 1 thioredoxin domain.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homodimer; disulfide-linked, upon oxidation (By similarity). May form heterodimers with AOP2.,

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U-Blot® Peroxiredoxin 1 Rabbit mAb

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U-Blot® Peroxiredoxin 1 Rabbit mAb

Product details

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