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Home/Reagents/Antibody/Primary antibody/Monoclonal Antibody/Mouse mAb/Podoplanin [ABT513] mouse mAb
SKU: WM1413 Categories: ,

Podoplanin [ABT513] mouse mAb

Ucallm_WM1413-50

Price range: $268.00 through $328.00

SKU: WM1413-50
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Product details

Background:
Podoplanin, also known as D2-40 or M2A, is a 38 kDa type I transmembrane mucin with multiple O-glycosylation sites. It is highly expressed in lymphatic endothelial cells, but not in blood vessels. In addition, it is also expressed in a variety of cells, such as mesothelial cells and type I alveolar epithelial cells, follicular dendritic cells, reticular cells, ovarian and testicular germ cells. Podoplanin is a very useful marker to distinguish malignant mesothelioma and adenocarcinoma, seminoma and follicular dendritic cell sarcoma. It is also the main choice to show and quantify lymphatic and intravascular tumor infiltration.

Specifications

Size50μL/100μL
TargetPodoplanin
ReactivityHuman
ApplicationsIHC, WB, IF, ELISA
MW(Calculated)24kD
MW(Observed)36kD
Host SpeciesMouse
IsotypeIgG1,Kappa
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
PurificationRecombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone NumberRMM513
ImmunogenSynthesized peptide derived from human Podoplanin AA range: 23-100
SpecificityThe antibody can specifically recognize human Podoplanin protein. In western blotting of U2O2 cell lysate, the antibody can label a 36 kDa band corresponding to Podoplanin.
Gene NamePDPN GP36 PSEC0003 PSEC0025
Protein NameAggrus Glycoprotein 36 Gp36 PA2.26 antigen T1-alpha T1A
Other NameAggrus; / Glycoprotein 36; / Gp36; / PA2.26 antigen; / T1-alpha; / T1A
SpeciesHuman
Gene ID10630
UniprotQ86YL7,
Species.1Mouse
Gene ID.114726
Uniprot.1Q62011,
Species.2Rat
Gene ID.254320
Uniprot.2Q64294
Cellular LocalizationCytoplasmic
Tissue ExpressionTonsil/ Appendix
Signaling_pathway
Research Areas
FunctionCaution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,Function:May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels.,PTM:Extensively O-glycosylated. Contains sialic acid residues. O-glycosylation is necessary for platelet aggregation activity.,PTM:The N-terminus is blocked.,similarity:Belongs to the podoplanin family.,subcellular location:Localized to actin-rich microvilli and plasma membrane projections such as filopodia, lamellipodia and ruffles.,tissue specificity:Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors and expressed in 25% of early oral squamous cell carcinomas.,
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