Name: U-Blot® PPIL1 Rabbit mAb
SKU: WR4695
Price: 268 USD
Availability: InStock

U-Blot® PPIL1 Rabbit mAb

Western Blot analysis of HepG2 whole cell lysates were separated by 4-20% SDS-PAGE, and the membrane was blotted with anti-PPIL1 rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG(H + L) antibody was used to detect the antibody.

WR4695 Western Blot analysis of HepG2 whole cell lysates were separated by 4-20% SDS-PAGE, and the membrane was blotted with anti-PPIL1 rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG(H + L) antibody was used to detect the antibody.

Price range: $268.00 through $328.00

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50μl

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SKU: WR4695-50

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Product details

Background:This gene is a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly conserved, ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. Based on similarity to other PPIases, this protein could accelerate the folding of proteins and might catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. [provided by RefSeq, Jul 2008]

Specifications

Target	PPIL1
Reactivity	Human
Applications	WB, FC
MW(Calculated)
MW(Observed)	19kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	WB 1:1000-5000; FC 1:100-300
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Source
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Purity
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	PT0789R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Sequence
Specificity	Endogenous
Gene Name	PPIL1; CYPL1; CGI-124; UNQ2425/PRO4984
Protein Name	Peptidyl-prolyl cis-trans isomerase-like 1; PPIase; Rotamase PPIL1
Other Name	PPIL1; / CYPL1; / CGI-124; / UNQ2425/PRO4984; / Peptidyl-prolyl cis-trans isomerase-like 1; / PPIase; / Rotamase PPIL1
Species	Human
Gene ID-1	51645
Uniprot	Q9Y3C6
Species.1
Gene ID-2
Uniprot.1
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Background	This gene is a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly conserved, ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. Based on similarity to other PPIases, this protein could accelerate the folding of proteins and might catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. [provided by RefSeq, Jul 2008]
Cellular Localization	Nucleus.
Tissue Expression	Ubiquitous, with the most abundant expression in heart and skeletal muscle.
Signaling_pathway
Research Areas
Function	Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:33220177). PPIases accelerate the folding of proteins. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:16595688). Catalyzes prolyl peptide bond isomerization in CDC40/PRP17 (PubMed:33220177). Plays an important role in embryonic brain development; this function is independent of its isomerase activity (PubMed:33220177). {ECO:0000269\|PubMed:11991638, ECO:0000269\|PubMed:16595688, ECO:0000269\|PubMed:28076346, ECO:0000269\|PubMed:28502770, ECO:0000269\|PubMed:33220177}.
RRID