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PSMD11 [PTR1354] mouse mAb
Ucallm_WM1377-50
Price range: $268.00 through $328.00
Product details
Background:
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S9 family that functions as a non-ATPase subunit of the 19S regulator and is phosphorylated by AMP-activated protein kinase. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq,
Specifications
| Size | 50μL/100μL |
| Target | PSMD11 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IF, ELISA |
| MW(Calculated) | 47kD |
| MW(Observed) | 47kD |
| Host Species | Mouse |
| Isotype | IgG3,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RMMR1354 |
| Immunogen | Synthesized peptide derived from human protein.AA range:250-350 |
| Specificity | This antibody detects endogenous levels of PSMD11. |
| Gene Name | PSMD11 |
| Protein Name | 26S proteasome non-ATPase regulatory subunit 11 |
| Other Name | PSMD11; / 26S proteasome non-ATPase regulatory subunit 11; / 26S proteasome regulatory subunit RPN6; / 26S proteasome regulatory subunit S9; / 26S proteasome regulatory subunit p44.5 |
| Species | Human |
| Gene ID | 5717 |
| Uniprot | O00231, |
| Species.1 | Mouse |
| Gene ID.1 | 69077 |
| Uniprot.1 | Q8BG32 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | |
| Tissue Expression | Highly expressed in embryonic stem cells (ESCs). Expression decreases as ESCs differentiate. |
| Signaling_pathway | Human Diseases >> Neurodegenerative disease >> Alzheimer disease;Human Diseases >> Neurodegenerative disease >> Parkinson disease;Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis;Human Diseases >> Neurodegenerative disease >> Huntington disease;Human Diseases >> Neurodegenerative disease >> Spinocerebellar ataxia;Human Diseases >> Neurodegenerative disease >> Prion disease;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases;Genetic Information Processing >> Folding, sorting and degradation >> Proteasome |
| Research Areas | >>Proteasome; / >>Alzheimer disease; / >>Parkinson disease; / >>Amyotrophic lateral sclerosis; / >>Huntington disease; / >>Spinocerebellar ataxia; / >>Prion disease; / >>Pathways of neurodegeneration - multiple diseases; / >>Epstein-Barr virus infection |
| Function | Function:Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.,similarity:Belongs to the proteasome subunit S9 family.,similarity:Contains 1 PCI domain.,subunit:Component of the PA700 complex., |
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