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PUMA Polyclonal Antibody
Ucallm_WP14139-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011],
Specifications
| Size | 50μL/100μL |
| Target | PUMA |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 23kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IF 1:100-300; ELISA 1:5000-20000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PUMA. AA range:120-169 |
| Specificity | PUMA Polyclonal Antibody detects endogenous levels of PUMA protein. |
| Gene Name | BBC3 |
| Protein Name | Bcl-2-binding component 3 |
| Other Name | BBC3; / PUMA; / Bcl-2-binding component 3; / JFY-1; / p53 up-regulated modulator of apoptosis |
| Species | Human |
| Gene ID | 27113 |
| Uniprot | Q9BXH1, |
| Species.1 | Mouse |
| Gene ID.1 | 170770 |
| Uniprot.1 | Q99ML1, |
| Species.2 | Rat |
| Gene ID.2 | 317673 |
| Uniprot.2 | Q80ZG6 |
| Cellular Localization | Mitochondrion . Localized to the mitochondria in order to induce cytochrome c release. |
| Tissue Expression | Ubiquitously expressed. |
| Signaling_pathway | Cellular Processes >> Cell growth and death >> Apoptosis;Cellular Processes >> Cell growth and death >> Apoptosis - multiple species;Cellular Processes >> Cell growth and death >> p53 signaling pathway;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: specific types >> Colorectal cancer;Human Diseases >> Neurodegenerative disease >> Huntington disease;Environmental Information Processing >> Signal transduction >> Hippo signaling pathway |
| Research Areas | >>Platinum drug resistance; / >>p53 signaling pathway; / >>Apoptosis; / >>Apoptosis - multiple species; / >>Hippo signaling pathway; / >>Huntington disease; / >>Measles; / >>Pathways in cancer; / >>Colorectal cancer |
| Function | Function:Essential mediator of p53-dependent and p53-independent apoptosis.,induction:By DNA damage, glucocorticoid treatment, growth factor deprivation and p53.,similarity:Belongs to the Bcl-2 family.,subcellular location:Localized to the mitochondria in order to induce cytochrome c release.,subunit:Interacts with MCL1 and BCL2A1 (By similarity). Interacts with BCL2 and BCL2L1/BCL-XL.,tissue specificity:Ubiquitously expressed., |
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