Name: U-Blot® Rab7 Rabbit mAb
SKU: WR4182
Price: 268 USD
Availability: InStock

U-Blot® Rab7 Rabbit mAb

Various whole cell lysates were separated by 4-20% SDS-PAGE, and the primary antibody was used at 4°C, over night with a 1:2500 dilution . The Dylight 800-conjugated Goat anti-Rabbit antibody(Cat:WS0446) was used to detect the antibody.

WR4182 Various whole cell lysates were separated by 4-20% SDS-PAGE, and the primary antibody was used at 4°C, over night with a 1:2500 dilution . The Dylight 800-conjugated Goat anti-Rabbit antibody(Cat:WS0446) was used to detect the antibody.

Western blot analysis of lysates from K562 cells, using Rab7 Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody (WS0002) was used to detect the antibody.

WR4182 Western blot analysis of lysates from K562 cells, using Rab7 Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody (WS0002) was used to detect the antibody.

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WR4182-50

Enter the quantity you would like, or drag the panel to find the quantity and price that best for you

Bulk Quote Authorize OEM & ODM

Product details

Background:RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	RAB7
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)	24kD
MW(Observed)	24kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:200-1:1000; WB 1:1000-1:5000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM0345R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	RAB7A RAB7
Protein Name	RAB7A
Other Name
Species	Human
Gene ID	7879
Uniprot	P51149,
Species.1	Mouse
Gene ID.1	19349
Uniprot.1	P51150,
Species.2	Rat
Gene ID.2	29448
Uniprot.2	P09527
Cellular Localization	Cytoplasm
Tissue Expression	Widely expressed; high expression found in skeletal muscle.
Signaling_pathway	Cellular Processes >> Transport and catabolism >> Phagosome;Cellular Processes >> Transport and catabolism >> Autophagy - animal;Cellular Processes >> Transport and catabolism >> Mitophagy - animal
Research Areas	>>Mitophagy - animal; / >>Autophagy - animal; / >>Endocytosis; / >>Phagosome; / >>Salmonella infection; / >>Amoebiasis; / >>Tuberculosis
Function	Disease:Defects in RAB7A are the cause of Charcot-Marie-Tooth disease type 2B (CMT2B) [MIM:600882]; also known as hereditary motor and sensory neuropathy II (HMSN2). CMT2B is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT2 group are characterized by signs of axonal regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. CMT2B is clinically characterized by marked distal muscle weakness and a high frequency of foot ulcers, infections and amputations of the toes. CMT2B inheritance is autosomal dominant.,Function:Involved in late endocytic transport. Contributes to the maturation of phagosomes (acidification).,sequence Caution:Wrong choice of frame.,similarity:Belongs to the small GTPase superfamily. Rab family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Interacts with RILP.,tissue specificity:Widely expressed; high expression found in skeletal muscle.,

Please login to post questions

U-Blot® Rab7 Rabbit mAb

Product details

Specifications

About Us

Support

Order

Menu

U-Blot® Rab7 Rabbit mAb

Product details

Specifications

Related products

U-Blot® MMP7 Rabbit mAb

U-Blot® Smad2 (Phospho Ser250) Rabbit mAb

U-Blot® PMS2 Rabbit mAb

U-Blot™ Phosphate Buffered Saline with Tween 20 (PBS-T), pH 7.4

U-Blot® CD86 Rabbit mAb

U-Blot® VEGF Receptor 1 Rabbit mAb

Customer Reviews

Menu