Price range: $268.00 through $328.00
Background:
This gene encodes a member of the GTR/RAG GTP-binding protein family. The encoded protein is a monomeric guanine nucleotide-binding protein which forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. The encoded protein promotes intracellular localization of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012],
| Target | Rag C |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA, IHC, CoIP |
| MW(Calculated) | |
| MW(Observed) | 44kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-300; IP 1:50-200; ELISA 1:2000-20000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human RRAGC. AA range:302-351 |
| Sequence | |
| Specificity | Rag C Polyclonal Antibody detects endogenous levels of Rag C protein. |
| Gene Name | RRAGC |
| Protein Name | Ras-related GTP-binding protein C |
| Other Name | RRAGC; / Ras-related GTP-binding protein C; / Rag C; / RagC; / GTPase-interacting protein 2; / TIB929 |
| Species | Human |
| Gene ID-1 | 64121 |
| Uniprot | Q9HB90, |
| Species.1 | Mouse |
| Gene ID-2 | 54170 |
| Uniprot.1 | Q99K70 |
| Species.2 | |
| Gene ID-3 | |
| Uniprot.2 | |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | This gene encodes a member of the GTR/RAG GTP-binding protein family. The encoded protein is a monomeric guanine nucleotide-binding protein which forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. The encoded protein promotes intracellular localization of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012], |
| Cellular Localization | Cytoplasm . Nucleus . Lysosome . Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA (PubMed:11073942). . |
| Tissue Expression | Lymph,Ovary, |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Autophagy - animal;Environmental Information Processing >> Signal transduction >> mTOR signaling pathway |
| Research Areas | >>Autophagy - animal; / >>mTOR signaling pathway; / >>Shigellosis |
| Function | Function:Has guanine nucleotide-binding activity but weak intrinsic GTPase activity.,similarity:Belongs to the GTR/RAG GTP-binding protein family.,subcellular location:Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA.,subunit:Forms a heterodimer with RRAGA in a sequence-independent manner. Binds GTP. Interacts with NOL8 and RRAGB., |
| RRID |
