Price range: $268.00 through $328.00
Background:
This gene encodes a nuclear protein that belongs to a family proteins that contain an RNA-binding motif. The encoded protein associates with hnRNP proteins and may be involved in regulating alternative splicing. Defects in this gene are the cause of the X-linked recessive disorder, TARP syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2011],
| Size | 50μL/100μL |
| Target | RBM10 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 102kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | RBM10 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | RBM10 DXS8237E GPATC9 GPATCH9 KIAA0122 |
| Protein Name | RNA-binding protein 10 (G patch domain-containing protein 9) (RNA-binding motif protein 10) (RNA-binding protein S1-1) (S1-1) |
| Other Name | |
| Species | Human |
| Gene ID | 8241 |
| Uniprot | P98175, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q99KG3, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P70501 |
| Cellular Localization | Nucleus . In the extranucleolar nucleoplasm constitutes hundreds of nuclear domains, which dynamically change their structures in a reversible manner. Upon globally reducing RNA polymerase II transcription, the nuclear bodies enlarge and decrease in number. They occur closely adjacent to nuclear speckles or IGCs (interchromatin granule clusters) but coincide with TIDRs (transcription-inactivation-dependent RNA domains). |
| Tissue Expression | Bone marrow,Brain,Colon,Epithelium,Fetal brain,Human endometrium,Liver,Lung |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A).,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence Caution:Translation N-terminally extended.,similarity:Contains 1 C2H2-type zinc finger.,similarity:Contains 1 G-patch domain.,similarity:Contains 1 RanBP2-type zinc finger.,similarity:Contains 2 RRM (RNA recognition motif) domains.,subcellular location:In the extranucleolar nucleoplasm constitutes hundreds of nuclear domains, which dynamically change their structures in a reversible manner. Upon globally reducing RNA polymerase II transcription, the nuclear bodies enlarge and decrease in number. They occur closely adjacent to nuclear speckles or IGCs (interchromatin granule clusters) but coincide with TIDRs (transcription-inactivation-dependent RNA domains).,subunit:Associates with the spliceosome. Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5., |
