Recombinant CD10 Fc-Fused Nanobody (VF0107)
Ucallm_WN0004
$365.00
Product details
Background:This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL).This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL.This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin.This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region ofThis
Specifications
| Size | 100μL |
| Target | CD10 |
| Reactivity | Human |
| Applications | ELISA |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | |
| Isotype | IgG2a,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | ELISA 1:5000-100000 |
| Formulation | Phosphate-buffered solution |
| Purification | Recombinant Expression and Affinity purified |
| Storage | -15°C to -25°C/1 year(Avoid freeze / thaw cycles) |
| Concentration | |
| Clonality | |
| Clone Number | VF0249 |
| Immunogen | Purified recombinant Human CD10 |
| Specificity | This recombinant monoclonal antibody can detects endogenous levels of CD10 protein. |
| Gene Name | MME EPN |
| Protein Name | Neprilysin |
| Other Name | MME; / EPN; / Neprilysin; / Atriopeptidase; / Common acute lymphocytic leukemia antigen; / CALLA; / Enkephalinase; / Neutral endopeptidase 24.11; / NEP; / Neutral endopeptidase; / Skin fibroblast elastase; / SFE; / CD antigen CD10 |
| Species | |
| Gene ID | |
| Uniprot | |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Single-pass type II membrane protein. |
| Tissue Expression | |
| Signaling_pathway | Organismal Systems >> Immune system >> Hematopoietic cell lineage;Organismal Systems >> Endocrine system >> Renin-angiotensin system;Human Diseases >> Neurodegenerative disease >> Alzheimer disease |
| Research Areas | |
| Function | Catalytic activity:Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'.,cofactor:Binds 1 zinc ion per subunit.,Disease:Important cell surface marker in the diagnostic of human acute lymphocytic leukemia.,enzyme regulation:Inhibited in a dose dependent manner by opiorphin.,Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Involved in the degradation of atrial natriuretic factor (ANF).,similarity:Belongs to the peptidase M13 family., |
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