Recombinant CD117 Fc-Fused Nanobody (VF0497)
Ucallm_WN0041
$365.00
Product details
Background:This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit.This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations inThis gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found forThis gene. [provided by RefSeq, Jul 2008]
Specifications
| Size | 100μL |
| Target | CD117 |
| Reactivity | Human |
| Applications | ELISA |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | |
| Isotype | IgG2a,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | ELISA 1:5000-100000 |
| Formulation | Phosphate-buffered solution |
| Purification | Recombinant Expression and Affinity purified |
| Storage | -15°C to -25°C/1 year(Avoid freeze / thaw cycles) |
| Concentration | Please check the information on the tube |
| Clonality | |
| Clone Number | VF0195 |
| Immunogen | Purified recombinant Human CD117 |
| Specificity | This recombinant monoclonal antibody can detects endogenous levels of CD117 protein. |
| Gene Name | KIT SCFR |
| Protein Name | Mast/stem cell growth factor receptor Kit (SCFR) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117) |
| Other Name | C Kit; / c-Kit; / c-Kit Ligand; / CD117; / Kit; / Kit Ligand; / KIT oncogene; / KIT proto oncogene receptor tyrosine kinase; / KIT_HUMAN; / Mast cell growth factor receptor; / Mast/stem cell growth factor receptor Kit; / MGF; / p145 c-kit; / PBT; / Piebald trait protein; / Proto oncogene c Kit; / Proto oncogene tyrosine protein kinase Kit; / Proto-oncogene c-Kit; / SCF Receptor; / SCFR; / soluble KIT variant 1; / Steel Factor Receptor; / Stem cell factor receptor; / tyrosine protein kinase Kit; / Tyrosine-protein kinase Kit; / v kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog; / v kit Hardy Zuckerman 4 feline sarcoma viral oncogene like protein; / v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
| Species | Human |
| Gene ID | 3815 |
| Uniprot | P10721 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Cytoplasm . Detected in the cytoplasm of spermatozoa, especially in the equatorial and subacrosomal region of the sperm head. . |
| Tissue Expression | Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth. |
| Signaling_pathway | Organismal Systems >> Immune system >> Hematopoietic cell lineage;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: overview >> Central carbon metabolism in cancer;Human Diseases >> Cancer: specific types >> Acute myeloid leukemia;Human Diseases >> Cancer: specific types >> Breast cancer;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway;Environmental Information Processing >> Signal transduction >> Ras signaling pathway;Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway;Environmental Information Processing >> Signal transduction >> Phospholipase D signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway |
| Research Areas | >>EGFR tyrosine kinase inhibitor resistance; / >>Endocrine resistance; / >>Platinum drug resistance; / >>MAPK signaling pathway; / >>ErbB signaling pathway; / >>Calcium signaling pathway; / >>HIF-1 signaling pathway; / >>PI3K-Akt signaling pathway; / >>Focal adhesion; / >>Adherens junction; / >>Tight junction; / >>Pathways in cancer; / >>Proteoglycans in cancer; / >>MicroRNAs in cancer; / >>Pancreatic cancer; / >>Endometrial cancer; / >>Prostate cancer; / >>Bladder cancer; / >>Non-small cell lung cancer; / >>Breast cancer; / >>Gastric cancer; / >>Central carbon metabolism in cancer |
| Function | Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,Disease:Defects in KIT are a cause of gastrointestinal stromal tumor (GIST) [MIM:606764].,Disease:Defects in KIT are a cause of piebaldism [MIM:172800]. Piebaldism is an autosomal dominant genetic developmental abnormality of pigmentation characterized by congenital patches of white skin and hair that lack melanocytes.,Disease:Defects in KIT have been associated with testicular tumors [MIM:273300]. It includes germ cell tumor (GCT) or testicular germ cell tumor (TGCT).,This is the receptor for stem cell factor (mast cell growth factor). It has a tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase (Pi3K).,online information:CD117 entry,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Interacts with APS. Interacts with MPDZ (via the tenth PDZ domain). Interacts with PTPRU., |
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