Recombinant CD131 Fc-Fused Nanobody (VF0307)
Ucallm_WN0068
$365.00
Product details
Background:CD131, also known as the IL-3R common β subunit , is a 95-120 kD type I transmembrane glycoprotein and belongs to the Ig superfamily. The common β subunit associates with the specific α subunits of IL-3 receptor, IL-5 receptor and GM-CSF receptor to form high affinity receptors for these cytokines. These cytokine receptors are expressed by neutrophils, eosinophils, monocytes, endothelial cells, fibroblasts and hematopoietic progenitor cells and play a crucial role in growth/activation of eosinophils and in the inflammatory response. The 1C1 antibody is a non-blocking antibody.
Specifications
| Size | 100μL |
| Target | CD131 |
| Reactivity | Human |
| Applications | ELISA |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | |
| Isotype | IgG2a,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | ELISA 1:5000-100000 |
| Formulation | Phosphate-buffered solution |
| Purification | Recombinant Expression and Affinity purified |
| Storage | -15°C to -25°C/1 year(Avoid freeze / thaw cycles) |
| Concentration | Please check the information on the tube |
| Clonality | |
| Clone Number | VF0123 |
| Immunogen | Purified recombinant Human CD131 |
| Specificity | This recombinant monoclonal antibody can detects endogenous levels of CD131 protein. |
| Gene Name | CSF2RB IL3RB IL5RB |
| Protein Name | Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131) |
| Other Name | IL-3R common β chain; / CDw131; / Beta-C antibody; / CD131 antibody; / CDw131 antibody; / Colony stimulating factor 2 receptor beta antibody; / Colony stimulating factor 2 receptor beta low affinity; / granulocyte macrophage; / antibody; / Common beta chain antibody; / Csf2rb antibody; / Cytokine receptor common beta chain antibody; / Cytokine receptor common beta chain precursor; / CDw131 antigen; / antibody; / Cytokine receptor common subunit beta antibody; / GM CSF/IL 3/IL 5 receptor common beta chain antibody; / GM-CSF/IL-3/IL-5 receptor common beta subunit antibody; / granulocyte-macrophage colony-stimulating factor receptor; / beta antibody; / IL3RB antibody; / IL3RB_HUMAN antibody; / IL5RB antibody; / Interleukin 3 receptor; / beta antibody; / Interleukin 3 receptor/granulocyte macrophage colony stimulating factor 3 receptor beta; / high affinity; / antibody; / Interleukin 5 receptor; / beta antibody; / SMDP5 antibody; / stimulating factor 3 receptor; / beta; / high affinity; / antibody |
| Species | Human |
| Gene ID | 1439 |
| Uniprot | P32927 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Membrane; Single-pass type I membrane protein. |
| Tissue Expression | Detected on hematopoietic stem cells derived from umbilical cord blood (PubMed:2474813). Detected on lymph vessel endothelial cells, skin and tonsil (PubMed:23169771). Detected on peripheral blood monocytes (PubMed:154873). Detected on monocyte-derived dendritic cells (at protein level) (PubMed:1635286). Detected at low levels in spleen, placenta, liver (PubMed:952422). Expressed by activated T-cells, B-cells, monocytes and thymic epithelial cells (PubMed:7767). Isoform 1 and isoform 3 are detected in vein and artery endothelial cells, astrocytes, keratinocytes and artery smooth muscle cells (PubMed:15496415). Expressed by neurons in the brain. Restricted expression in tumor cell lines. Detected in highly metastasizing melanoma cell lines (PubMed:952422). |
| Signaling_pathway | Cellular Processes >> Cell growth and death >> Apoptosis;Human Diseases >> Cancer: overview >> Pathways in cancer;Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction |
| Research Areas | |
| Function | Cell surface receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA (PubMed:1495999). In turn, participates in various signaling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway (PubMed:9516124). |
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