Recombinant CD134 Fc-Fused Nanobody (VF0317)
Ucallm_WN0080
$365.00
Product details
Background:CD134, also known as OX40 and TNFRSF4, is a 50 kD type I transmembrane glycoprotein. It is a member of the TNF receptor family. OX40 is expressed on activated T lymphocytes including Th1, Th2, Th17, and Treg cells. The interaction of OX40 with OX40L results in B cell proliferation and antibody secretion, regulation of primary T cell expansion, and T cell survival. OX40 influences the size of the T cell memory pool and regulation of CD4+ T cell tolerance.
Specifications
| Size | 100μL |
| Target | CD134 |
| Reactivity | Human |
| Applications | ELISA |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | |
| Isotype | IgG2a,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | ELISA 1:5000-100000 |
| Formulation | Phosphate-buffered solution |
| Purification | Recombinant Expression and Affinity purified |
| Storage | -15°C to -25°C/1 year(Avoid freeze / thaw cycles) |
| Concentration | Please check the information on the tube |
| Clonality | |
| Clone Number | VF0003 |
| Immunogen | Purified recombinant Human CD134 |
| Specificity | This recombinant monoclonal antibody can detects endogenous levels of CD134 protein. |
| Gene Name | TNFRSF4 TXGP1L |
| Protein Name | Tumor necrosis factor receptor superfamily member 4 (ACT35 antigen) (OX40L receptor) (TAX transcriptionally-activated glycoprotein 1 receptor) (CD antigen CD134) |
| Other Name | ACT 35 antibody; / ACT35 antibody; / ACT35 antigen antibody; / ATC35 antigen antibody; / CD 134 antibody; / CD134 antibody; / CD134 antigen antibody; / IMD16 antibody; / Lymphoid activation antigene ACT35 antibody; / OX 40 antibody; / OX40 antibody; / OX40 antigen antibody; / OX40 cell surface antigen antibody; / OX40 homologue antibody; / OX40L receptor antibody; / TAX transcriptionally activated glycoprotein 1 receptor antibody; / TAX transcriptionally-activated glycoprotein 1 receptor antibody; / TNF receptor superfamily member 4 antibody; / TNFRSF 4 antibody; / TNFRSF4 antibody; / TNR4_HUMAN antibody; / Tumor necrosis factor receptor superfamily member 4 antibody; / Txgp 1l antibody; / Txgp1 antibody; / Txgp1l antibody |
| Species | Human |
| Gene ID | 7293 |
| Uniprot | P43489 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Membrane; Single-pass type I membrane protein. |
| Tissue Expression | Ubiquitous but not detectable in peripheral blood lymphocytes or granulocytes. Weakly expressed in resting monocytes. Expressed in dendritic cells derived from monocytes. Expressed in epithelial cells of sinonasal tissue. Expressed in extravillous trophoblast cells and Hofbauer cells of the first trimester placenta and term placenta. |
| Signaling_pathway | Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction |
| Research Areas | |
| Function | Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity. (Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B. |
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